Control of the Embryonic Stem Cell State

被引：941

作者：

Young, Richard A. ^{[1
,2
]}

机构：

[1] Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

[2] MIT, Dept Biol, Cambridge, MA 02142 USA

来源：

CELL | 2011年 / 144卷 / 06期

关键词：

RNA-POLYMERASE-II; TRANSCRIPTIONAL REGULATORY CIRCUITRY; DE-LANGE-SYNDROME; PROTEIN-INTERACTION NETWORK; MAMMALIAN MEDIATOR COMPLEX; LEUKEMIA INHIBITORY FACTOR; POLYCOMB TARGET GENES; LONG NONCODING RNA; MOUSE ES CELLS; SELF-RENEWAL;

D O I：

10.1016/j.cell.2011.01.032

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Embryonic stem cells and induced pluripotent stem cells hold great promise for regenerative medicine. These cells can be propagated in culture in an undifferentiated state but can be induced to differentiate into specialized cell types. Moreover, these cells provide a powerful model system for studies of cellular identity and early mammalian development. Recent studies have provided insights into the transcriptional control of embryonic stem cell state, including the regulatory circuitry underlying pluripotency. These studies have, as a consequence, uncovered fundamental mechanisms that control mammalian gene expression, connect gene expression to chromosome structure, and contribute to human disease.

引用

页码：940 / 954

页数：15

共 198 条

[1] Nuclear CDKs Drive Smad Transcriptional Activation and Turnover in BMP and TGF-β Pathways [J].

Alarcon, Claudio ;

Zaromytidou, Alexia-Ileana ;

Xi, Qiaoran ;

Gao, Sheng ;

Yu, Jianzhong ;

Fujisawa, Sho ;

Barlas, Afsar ;

Miller, Alexandria N. ;

Manova-Todorova, Katia ;

Macias, Maria J. ;

Sapkota, Gopal ;

Pan, Duojia ;

Massague, Joan .

CELL, 2009, 139 (04) :757-769

[2] Modulation of the activity of multiple transcriptional activation domains by the DNA binding domains mediates the synergistic action of Sox2 and Oct-3 on the Fibroblast growth factor-4 enhancer [J].

Ambrosetti, DC ;

Schöler, HR ;

Dailey, L ;

Basilico, C .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (30) :23387-23397

[3] Multipotent cell lineages in early mouse development depend on SOX2 function [J].

Avilion, AA ;

Nicolis, SK ;

Pevny, LH ;

Perez, L ;

Vivian, N ;

Lovell-Badge, R .

GENES & DEVELOPMENT, 2003, 17 (01) :126-140

[4] Chromatin signatures of pluripotent cell lines [J].

Azuara, V ;

Perry, P ;

Sauer, S ;

Spivakov, M ;

Jorgensen, HF ;

John, RM ;

Gouti, M ;

Casanova, M ;

Warnes, G ;

Merkenschlager, M ;

Fisher, AG .

NATURE CELL BIOLOGY, 2006, 8 (05) :532-U189

[5] MicroRNAs: Target Recognition and Regulatory Functions [J].

Bartel, David P. .

CELL, 2009, 136 (02) :215-233

[6] Activin A maintains pluripotency of human embryonic stem cells in the absence of feeder layers [J].

Beattie, GM ;

Lopez, AD ;

Bucay, N ;

Hinton, A ;

Firpo, MT ;

King, CC ;

Hayek, A .

STEM CELLS, 2005, 23 (04) :489-495

[7] An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors [J].

Ben-Porath, Ittai ;

Thomson, Matthew W. ;

Carey, Vincent J. ;

Ge, Ruping ;

Bell, George W. ;

Regev, Aviv ;

Weinberg, Robert A. .

NATURE GENETICS, 2008, 40 (05) :499-507

[8]

BENSHUSHAN E, 1995, MOL CELL BIOL, V15, P1034

[9] A bivalent chromatin structure marks key developmental genes in embryonic stem cells [J].

Bernstein, BE ;

Mikkelsen, TS ;

Xie, XH ;

Kamal, M ;

Huebert, DJ ;

Cuff, J ;

Fry, B ;

Meissner, A ;

Wernig, M ;

Plath, K ;

Jaenisch, R ;

Wagschal, A ;

Feil, R ;

Schreiber, SL ;

Lander, ES .

CELL, 2006, 125 (02) :315-326

[10] The landscape of somatic copy-number alteration across human cancers [J].

Beroukhim, Rameen ;

Mermel, Craig H. ;

Porter, Dale ;

Wei, Guo ;

Raychaudhuri, Soumya ;

Donovan, Jerry ;

Barretina, Jordi ;

Boehm, Jesse S. ;

Dobson, Jennifer ;

Urashima, Mitsuyoshi ;

Mc Henry, Kevin T. ;

Pinchback, Reid M. ;

Ligon, Azra H. ;

Cho, Yoon-Jae ;

Haery, Leila ;

Greulich, Heidi ;

Reich, Michael ;

Winckler, Wendy ;

Lawrence, Michael S. ;

Weir, Barbara A. ;

Tanaka, Kumiko E. ;

Chiang, Derek Y. ;

Bass, Adam J. ;

Loo, Alice ;

Hoffman, Carter ;

Prensner, John ;

Liefeld, Ted ;

Gao, Qing ;

Yecies, Derek ;

Signoretti, Sabina ;

Maher, Elizabeth ;

Kaye, Frederic J. ;

Sasaki, Hidefumi ;

Tepper, Joel E. ;

Fletcher, Jonathan A. ;

Tabernero, Josep ;

Baselga, Jose ;

Tsao, Ming-Sound ;

Demichelis, Francesca ;

Rubin, Mark A. ;

Janne, Pasi A. ;

Daly, Mark J. ;

Nucera, Carmelo ;

Levine, Ross L. ;

Ebert, Benjamin L. ;

Gabriel, Stacey ;

Rustgi, Anil K. ;

Antonescu, Cristina R. ;

Ladanyi, Marc ;

Letai, Anthony .

NATURE, 2010, 463 (7283) :899-905

← 1 2 3 4 5 6 7 8 9 10 →