Synthesis and collateral dilator activity of nitroxyalkylamides having direct or latent sulfhydryl moieties

被引：7

作者：

Ishihara, S ^{[1
]}

Saito, F

Ohhata, Y

Kanai, M

Mizuno, H

Fujisawa, M

Yorikane, R

Koike, H

机构：

[1] Sankyo Co Ltd, Res Labs, Shinagawa Ku, Tokyo 140, Japan

[2] Chemtech Labo Inc, Shinagawa Ku, Tokyo 140, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 09期

关键词：

D O I：

10.1016/S0960-894X(03)00199-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

To develop an orally active, long-acting nitrate that does not induce tolerance, nitroxyalkyl compounds were prepared and their activities evaluated by the use of carotid collaterals in anesthetized dogs. A compound having a favorable pharmacological profile, that is, long-lasting collateral vasodilatation and little hypotension, and lack of nitrate tolerance, was chosen for further evaluation. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：1527 / 1530

页数：4

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