Synthesis of pyrimido[6,1-a]isoquinolines via a one-pot, four-component reaction

被引：20

作者：

Alizadeh, Abdolali ^{[1
]}

Rezvanian, Atieh ^{[1
]}

Zhu, Log-Guan ^{[2
]}

机构：

[1] Tarbiat Modares Univ, Dept Chem, Tehran 14115, Iran

[2] Zhejiang Univ, Dept Chem, Hangzhou 310027, Zhejiang, Peoples R China

来源：

TETRAHEDRON | 2010年 / 66卷 / 34期

关键词：

Trichloromethylchloroformate; Alkyl acetoacetates; Enaminone; Pyrimido-isoquinoline; Four-component reaction; MULTICOMPONENT REACTION; SATURATED HETEROCYCLES; DERIVATIVES; ENAMINONES; INHIBITORS; ISOCYANATE; ANNULATION; EFFICIENT; KINASE;

D O I：

10.1016/j.tet.2010.06.033

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学];

摘要：

An efficient one-pot synthesis of pyrimido[6,1-a]isoquinoline-1-carboxylate derivatives is described. This involves the four-component reaction between primary amines, alkyl acetoacetates, isoquinoline and trichloromethylchloroformate (diphosgene) under mild conditions at ambient temperature. (C) 2010 Elsevier Ltd. All rights reserved.

引用

收藏

页码：6924 / 6927

页数：4

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