Cutting edge: Type IIFNs provide a third signal to CD8 T cells to stimulate clonal expansion and differentiation

被引：511

作者：

Curtsinger, JM ^{[1
]}

Valenzuela, JO ^{[1
]}

Agarwal, P ^{[1
]}

Lins, D ^{[1
]}

Mescher, MF ^{[1
]}

机构：

[1] Univ Minnesota, Ctr Immunol, Dept Lab Med & Pathol, Minneapolis, MN 55455 USA

来源：

JOURNAL OF IMMUNOLOGY | 2005年 / 174卷 / 08期

关键词：

D O I：

10.4049/jimmunol.174.8.4465

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

In this study, we show that IFN-alpha beta can have a direct role in linking innate and adaptive responses by providing the "third signal" needed by naive CD8 T cells responding to Ag and costimulatory ligands. Stimulation of CD8 T cells in the absence of a third signal leads to proliferation, but clonal expansion is limited by poor survival and effector functions do not develop. We show that IFN-alpha beta can provide the third signal directly to CD8 T cells via a STAT4-dependent pathway to stimulate survival, development of cytolytic function, and production of IFN-gamma. Provision of the third signal by either IFN-alpha beta or IL-12 results in regulation of the expression of a number of genes, including several that encode proteins critical for effector function.

引用

页码：4465 / 4469

页数：5

共 24 条

[1]

The CD8α+ dendritic cell is responsible for inducing peripheral self-tolerance to tissue-associated antigens [J].