Genetic association of acyl-coenzyme A:: cholesterol acyltransferase with cerebrospinal fluid cholesterol levels, brain amyloid load, and risk for Alzheimer's disease

被引：53

作者：

Wollmer, MA

Streffer, JR

Tsolaki, M

Grimaldi, LME

Lütjohann, D

Thal, D

von Bergmann, K

Nitsch, RM

Hock, C

Papassotiropoulos, A

机构：

[1] Univ Zurich, Div Psychiat Res, CH-8029 Zurich, Switzerland

[2] Aristotle Univ Thessaloniki, Dept Neurol 3, GR-54006 Thessaloniki, Greece

[3] IRCCS, Neuroimmunol Unit, Dept Neurosci, H San Raffaele, Italy

[4] AUSL 2, Dept Neurosci, Caltanissetta, Italy

[5] Univ Bonn, Med Ctr, Dept Clin Pharmacol, D-5300 Bonn, Germany

[6] Univ Bonn, Med Ctr, Inst Neuropathol, D-5300 Bonn, Germany

来源：

MOLECULAR PSYCHIATRY | 2003年 / 8卷 / 06期

关键词：

SNP; polymorphism; ACAT1; SOAT1; case-control study; dementia;

D O I：

10.1038/sj.mp.4001296

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A common polymorphism of the gene encoding acylcoenzyme A: cholesterol acyltransferase 1 (SOAT1), which is involved in the regulation of beta-amyloid peptide generation, is associated with low brain amyloid load (P = 0.03) and with low cerebrospinal fluid levels of cholesterol (P = 0.005). This polymorphism of SOAT1 is also associated with reduced risk for Alzheimer's disease in ethnically distinct populations (P = 0.0001, odds ratio: 0.6, 95% confidence interval 0.4-0.8).

引用

页码：635 / 638

页数：4

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