An N-heterocyclic carbene ligand with flexible steric bulk allows Suzuki cross-coupling of sterically hindered aryl chlorides at room temperature

被引：439

作者：

Altenhoff, G ^{[1
]}

Goddard, R ^{[1
]}

Lehmann, CW ^{[1
]}

Glorius, F ^{[1
]}

机构：

[1] Max Planck Inst Kohlenforsch, D-45470 Mulheim, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 31期

关键词：

biaryls; carbene ligands; C-C coupling; cross-coupling; palladium;

D O I：

10.1002/anie.200351325

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A juggling act: The steric bulk of the ligand enhances reductive elimination in the Pd-catalyzed Suzuki cross-coupling. However, it impedes the oxidative addition and transmetallation of sterically hindered substrates. This dilemma is solved with the carbene ligand 1, which exhibits flexible steric bulk.

引用

页码：3690 / 3693

页数：4

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