Insights into viral transmission at the uterine-placental interface

被引:105
作者
Pereira, L [1 ]
Maidji, E [1 ]
McDonagh, S [1 ]
Tabata, T [1 ]
机构
[1] Univ Calif San Francisco, Dept Cell & Tissue Biol, San Francisco, CA 94143 USA
关键词
D O I
10.1016/j.tim.2005.02.009
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
During human gestation, viruses can cause intrauterine infections associated with pregnancy complications and fetal abnormalities. The ability of viruses to spread from the infected mother to the fetus arises from the architecture of the placenta, which anchors the fetus to the uterus. Placental cytotrophoblasts differentiate, assume an endothelial phenotype, breach uterine blood vessels and form a hybrid vasculature that amplifies the maternal blood supply for fetal development. Human cytomegalovirus the major cause of congenital disease- infects the uterine wall and the adjacent placenta, suggesting adaptation for pathogen survival in this microenvironment. Infection of villus explants and differentiating and/or invading cytotrophoblasts offers an in vitro model for studying viruses associated with prenatal infections.
引用
收藏
页码:164 / 174
页数:11
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