Combined effects of mild hypothermia and glycoprotein IIb/IIIa antagonists on platelet-platelet and leukocyte-platelet aggregation

被引：29

作者：

Frelinger, AL

Furman, MI

Barnard, MR

Krueger, LA

Dae, MW

Michelson, AD

机构：

[1] Univ Massachusetts, Sch Med, Div Cardiovasc Med, Ctr Platelet Funct Studies, Worcester, MA 01655 USA

[2] Univ Massachusetts, Sch Med, Dept Pediat, Worcester, MA 01655 USA

[3] Univ Massachusetts, Sch Med, Dept Med, Worcester, MA 01655 USA

[4] Univ Calif San Francisco, Cardiovasc Res Inst, San Francisco, CA 94143 USA

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 2003年 / 92卷 / 09期

关键词：

D O I：

10.1016/j.amjcard.2003.06.007

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Endovascular cooling was assessed as a potential treatment for percutaneous coronary intervention in patients with acute myocardial infarction. Here we show that mild hypothermia: (1) inhibits platelet aggregation; (2) augments eptifibatide- and tirofiban- but not abciximab-induced inhibition of platelet aggregation; (3) increases the formation of adenosine diphosphate-induced leukocyte-platelet aggregates; and (4) diminishes the glycoprotein IIb/IIIa antagonist-induced decrease in leukocyte-platelet aggregates. (C) 2003 by Excerpta Medica, Inc.

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收藏

页码：1099 / 1101

页数：3

相关论文

共 14 条

[1]

Coller BS, 1997, CIRCULATION, V96, P3828

[2] Platelet GPIIb/IIIa antagonists: The first anti-integrin receptor therapeutics [J].

Coller, BS .

JOURNAL OF CLINICAL INVESTIGATION, 1997, 99 (07) :1467-1471

[3] Effect of endovascular cooling on myocardial temperature, infarct size, and cardiac output in human-sized pigs [J].

Dae, MW ;

Gao, DW ;

Sessler, DI ;

Chair, K ;

Stillson, CA .

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2002, 282 (05) :H1584-H1591

[4] Induction of mild systemic hypothermia with endovascular cooling during primary percutaneous coronary intervention for acute myocardial infarction [J].

Dixon, SR ;

Whitbourn, RJ ;

Dae, MW ;

Grube, E ;

Sherman, W ;

Schaer, GL ;

Jenkins, S ;

Baim, DS ;

Gibbons, RJ ;

Kuntz, RE ;

Popma, JJ ;

Nguyen, TT ;

O'Neill, WW .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2002, 40 (11) :1928-1934

[5] Regional hypothermia reduces myocardial necrosis even when instituted after the onset of ischemia [J].

Hale, SL ;

Dave, RH ;

Kloner, RA .

BASIC RESEARCH IN CARDIOLOGY, 1997, 92 (05) :351-357

[6]

MICHELSON AD, 1994, THROMB HAEMOSTASIS, V71, P633

[7] The effects of aspirin and hypothermia on platelet function in vivo [J].

Michelson, AD ;

Barnard, MR ;

Khuri, SF ;

Rohrer, MJ ;

MacGregor, H ;

Valeri, CR .

BRITISH JOURNAL OF HAEMATOLOGY, 1999, 104 (01) :64-68

[8] Mild Hypothermia reduces infarct size in the beating rabbit heart: A practical intervention for acute myocardial infarction? [J].

Miki, T ;

Liu, GS ;

Cohen, MV ;

Downey, JM .

BASIC RESEARCH IN CARDIOLOGY, 1998, 93 (05) :372-383

[9] Labeling of the internal pool of GP IIb-IIIa in platelets by c7E3 Fab fragments (abciximab):: Flow and endocytic mechanisms contribute to the transport [J].

Nurden, P ;

Poujol, C ;

Durrieu-Jais, C ;

Winckler, J ;

Combrié, R ;

Macchi, L ;

Bihour, C ;

Wagner, C ;

Jordan, R ;

Nurden, AT .

BLOOD, 1999, 93 (05) :1622-1633

[10] Antithrombotic therapy in patients undergoing percutaneous coronary intervention [J].

Popma, JJ ;

Ohman, EM ;

Weitz, J ;

Lincoff, M ;

Harrington, RA ;

Berger, P .

CHEST, 2001, 119 (01) :321S-336S