Characterization of the proteome, diseases and evolution of the human postsynaptic density

被引：353

作者：

Bayes, Alex ^{[1
]}

van de Lagemaat, Louie N. ^{[1
]}

Collins, Mark O.

Croning, Mike D. R. ^{[1
]}

Whittle, Ian R. ^{[2
]}

Choudhary, Jyoti S.

Grant, Seth G. N. ^{[1
]}

机构：

[1] Wellcome Trust Sanger Inst, Genes Cognit Programme, Hinxton, Cambs, England

[2] Univ Edinburgh, Div Clin Neurosci, Edinburgh, Midlothian, Scotland

来源：

NATURE NEUROSCIENCE | 2011年 / 14卷 / 01期

基金：

美国国家卫生研究院; 英国医学研究理事会; 英国惠康基金;

关键词：

PHENOTYPE ONTOLOGY; SCHIZOPHRENIA; TOOL;

D O I：

10.1038/nn.2719

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We isolated the postsynaptic density from human neocortex (hPSD) and identified 1,461 proteins. hPSD mutations cause 133 neurological and psychiatric diseases and were enriched in cognitive, affective and motor phenotypes underpinned by sets of genes. Strong protein sequence conservation in mammalian lineages, particularly in hub proteins, indicates conserved function and organization in primate and rodent models. The hPSD is an important structure for nervous system disease and behavior.

引用

页码：19 / 21

页数：3

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