Validity of the executive function theory of attention-deficit/hyperactivity disorder: A meta-analytic review

被引:2422
作者
Willcutt, EG
Doyle, AE
Nigg, JT
Faraone, SV
Pennington, BF
机构
[1] Univ Colorado, Dept Psychol, Boulder, CO 80309 USA
[2] Massachusetts Gen Hosp, Boston, MA 02114 USA
[3] Harvard Univ, Sch Med, Boston, MA 02115 USA
[4] Michigan State Univ, Denver, CO USA
[5] SUNY Upstate Med Univ, Denver, CO USA
[6] Univ Denver, Denver, CO USA
基金
美国国家卫生研究院;
关键词
attention-deficit/hyperactivity disorder; executive function; meta-analysis; neuropsychology; subtypes;
D O I
10.1016/j.biopsych.2005.02.006
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
One of the most prominent neuropsychologic theories of attention-deficit/hyperactivity disorder (ADHD) suggests that its symptoms arise from a primary deficit in executive functions (EF), defined as neurocognitive processes that maintain an appropriate problem-solving set to attain a later goal. To examine the validity of the EF theory, we conducted a meta-analysis of 83 studies that administered EF measures to groups with ADHD (total N = 3734) and without ADHD (N = 2969). Groups with ADHD exhibited significant impairment on all LT tasks. Effect sizes for all measures fell in the medium range (.46-69), but the strongest and most consistent effects were obtained on measures of response inhibition, vigilance, working memory, and planning. Weaknesses in EF were significant in both clinic-referred and community samples and were not explained by group differences in intelligence, academic achievement, or symptoms of other disorders. ADHD is associated with significant weaknesses in several key EF domains. However, moderate effect sizes and lack of universality of EF deficits among individuals with ADHD suggest that EF weaknesses are neither necessary nor sufficient to cause all cases of ADHD. Difficulties with EF appear to be one important component of the complex neuropychology of ADHD.
引用
收藏
页码:1336 / 1346
页数:11
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