Imaging of dopamine transporters in humans with technetium-99m TRODAT-1

被引：257

作者：

Kung, HF

Kim, HJ

Kung, MP

Meegalla, SK

Plossl, K

Lee, HK

机构：

[1] UNIV PENN,DEPT PHARMACOL,PHILADELPHIA,PA 19104

[2] ASAN MED CTR,DEPT NUCL MED,SEOUL,SOUTH KOREA

来源：

EUROPEAN JOURNAL OF NUCLEAR MEDICINE | 1996年 / 23卷 / 11期

关键词：

technetium-99m; single-photon emission tomography; basal ganglia; brain; Parkinson's syndrome;

D O I：

10.1007/BF01254479

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Technetium-99m TRODAT-1, a tropane derivative, has shown promise as a tracer for the imaging of dopamine transporters in preliminary studies in rats and baboons. The present report concerns the first study of the use of [Tc-99m]TRODAT-1 for the same purpose in humans. The specific uptake of [Tc-99m]TRODAT-1 in dopamine transporter sites located in the basal ganglia area was confirmed: the best contrast between the basal ganglia and the occipital area, which is devoid of dopamine transporters, was achieved at 120-140 min following injection. The development of a Tc-99m-based agent bypasses the need for cyclotron-produced radionuclides, which will be of benefit for routine clinical studies.

引用

页码：1527 / 1530

页数：4

共 10 条

[1]

[Anonymous], 1991, BIOCH BASIS NEUROPHA

[2] MAPPING COCAINE BINDING-SITES IN HUMAN AND BABOON BRAIN INVIVO [J].

FOWLER, JS ;

VOLKOW, ND ;

WOLF, AP ;

DEWEY, SL ;

SCHLYER, DJ ;

MACGREGOR, RR ;

HITZEMANN, R ;

LOGAN, J ;

BENDRIEM, B ;

GATLEY, SJ ;

CHRISTMAN, D .

SYNAPSE, 1989, 4 (04) :371-377

[3] POSITRON EMISSION TOMOGRAPHIC IMAGING OF THE DOPAMINE TRANSPORTER WITH C-11 WIN 35,428 REVEALS MARKED DECLINES IN MILD PARKINSONS-DISEASE [J].

FROST, JJ ;

ROSIER, AJ ;

REICH, SG ;

SMITH, JS ;

EHLERS, MD ;

SNYDER, SH ;

RAVERT, HT ;

DANNALS, RF .

ANNALS OF NEUROLOGY, 1993, 34 (03) :423-431

[4] SINGLE-PHOTON EMISSION COMPUTED TOMOGRAPHIC IMAGING DEMONSTRATES LOSS OF STRIATAL DOPAMINE TRANSPORTERS IN PARKINSON DISEASE [J].

INNIS, RB ;

SEIBYL, JP ;

SCANLEY, BE ;

LARUELLE, M ;

ABI-DARGHAM, A ;

WALLACE, E ;

BALDWIN, RM ;

ZEAPONCE, Y ;

ZOGHBI, S ;

WANG, S ;

GAO, Y ;

NEUMEYER, JL ;

CHARNEY, DS ;

HOFFER, PB ;

MAREK, KL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (24) :11965-11969

[5] NEW TC-99M-LABELED BRAIN PERFUSION IMAGING AGENTS [J].

KUNG, HF .

SEMINARS IN NUCLEAR MEDICINE, 1990, 20 (02) :150-158

[6]

KUNG HF, 1990, J LABELLED COMPD RAD, V30, P29

[7] Tc-99m-labeled tropanes as dopamine transporter imaging agents [J].

Meegalla, S ;

Plossl, K ;

Kung, MP ;

Chumpradit, S ;

Stevenson, DA ;

Frederick, D ;

Kung, HF .

BIOCONJUGATE CHEMISTRY, 1996, 7 (04) :421-429

[8] FIRST EXAMPLE OF A TC-99M COMPLEX AS A DOPAMINE TRANSPORTER IMAGING AGENT [J].

MEEGALLA, S ;

PLOSSL, K ;

KUNG, MP ;

SVENSON, DA ;

LIABLESANDS, LM ;

RHEINGOLD, AL ;

KUNG, HF .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1995, 117 (44) :11037-11038

[9]

Mozley PD, 1996, J NUCL MED, V37, P151

[10]

YUNG BCK, 1993, J NUCL MED, V34, P197

← 1 →