Mitochondrial Regulation of Oxygen Sensing

被引：76

作者：

Chandel, Navdeep S. ^{[1
]}

机构：

[1] Northwestern Univ, Dept Med, Div Pulm & Crit Care Med, Chicago, IL 60601 USA

来源：

MEMBRANE RECEPTORS, CHANNELS AND TRANSPORTERS IN PULMONARY CIRCULATION | 2010年 / 661卷

关键词：

Mitochondria; HIF; ROS; Na/K ATPase; HYPOXIA-INDUCIBLE FACTOR; ALVEOLAR EPITHELIAL-CELLS; PROTEIN-KINASE-C; COMPLEX-III; HIF-ALPHA; TRANSCRIPTIONAL ACTIVITY; INDUCED ENDOCYTOSIS; HYDROGEN-PEROXIDE; RESPIRATORY-CHAIN; ELECTRON-TRANSFER;

D O I：

10.1007/978-1-60761-500-2_22

中图分类号：

Q [生物科学];

学科分类号：

090105 [作物生产系统与生态工程];

摘要：

Hypoxia promotes physiological processes such as energy metabolism, angiogenesis, cell proliferation, and cell viability through the transcription factor Hypoxia Inducible Factor (HIF). Hypoxia also diminishes the activity of ATP consuming processes to promote cell survival. The mechanism(s) by which hypoxia activates HIF and diminishes ATP demand are a subject of intensive research. Here we outline the model in which mitochondrial complex III regulate the activity of HIF and diminish ATP utilization processes through the increased production of ROS during hypoxia.

引用

页码：339 / 354

页数：16

共 63 条

[1]

The role of mitochondria in the regulation of hypoxia-inducible factor 1 expression during hypoxia [J].

Agani, FH ;

Pichiule, P ;

Chavez, JC ;

LaManna, JC .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (46) :35863-35867

[2]

AW TY, 1982, J BIOL CHEM, V257, P8997

[3]

The Qo site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production [J].

Bell, Eric L. ;

Klimova, Tatyana A. ;

Eisenbart, James ;

Moraes, Carlos T. ;

Murphy, Michael P. ;

Budinger, G. R. Scott ;

Chandel, Navdeep S. .

JOURNAL OF CELL BIOLOGY, 2007, 177 (06) :1029-1036

[4]

ROLE OF UBIQUINONE IN MITOCHONDRIAL GENERATION OF HYDROGEN-PEROXIDE [J].

BOVERIS, A ;

CADENAS, E ;

STOPPANI, AOM .

BIOCHEMICAL JOURNAL, 1976, 156 (02) :435-444

[5]

Oxygen sensing in the hypoxic response pathway: regulation of the hypoxia-inducible transcription factor [J].

Bruick, RK .

GENES & DEVELOPMENT, 2003, 17 (21) :2614-2623

[6]

Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation [J].

Brunelle, JK ;

Bell, EL ;

Quesada, NM ;

Vercauteren, K ;

Tiranti, V ;

Zeviani, M ;

Scarpulla, RC ;

Chandel, NS .

CELL METABOLISM, 2005, 1 (06) :409-414

[7]

Oxygen sensing and molecular adaptation to hypoxia [J].

Bunn, HF ;

Poyton, RO .

PHYSIOLOGICAL REVIEWS, 1996, 76 (03) :839-885

[8]

Hypoxia reversibly inhibits epithelial sodium transport but does not inhibit lung ENaC or Na-K-ATPase expression [J].

Carpenter, TC ;

Schomberg, S ;

Nichols, C ;

Stenmark, KR ;

Weil, JV .

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2003, 284 (01) :L77-L83

[9]

Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1α during hypoxia -: A mechanism of O2 sensing [J].

Chandel, NS ;

McClintock, DS ;

Feliciano, CE ;

Wood, TM ;

Melendez, JA ;

Rodriguez, AM ;

Schumacker, PT .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (33) :25130-25138

[10]

Molecular oxygen modulates cytochrome c oxidase functions [J].

Chandel, NS ;

Budinger, GRS ;

Schumacker, PT .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (31) :18672-18677

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