Hypothesis: Myostatin is a mediator of cardiac cachexia

被引:12
作者
Hoenig, Michel R. [1 ]
机构
[1] Royal Brisbane & Womens Hosp, D7 Off, Herston, Qld 4029, Australia
关键词
cachexia; myostatin; neurohumoral; heart failure;
D O I
10.1016/j.ijcard.2007.07.058
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Myostatin is a recently described negative regulator of skeletal muscle mass. This paper hypothesizes a role for this system in cardiac cachexia and insulin resistance and osteoporosis associated with advanced heart failure. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:131 / 133
页数:3
相关论文
共 19 条
[1]   Cytokines and neurohormones relating to body composition alterations in the wasting syndrome of chronic heart failure [J].
Anker, SD ;
Ponikowski, PP ;
Clark, AL ;
Leyva, F ;
Rauchhaus, M ;
Kemp, M ;
Teixeira, MM ;
Hellewell, PG ;
Hooper, J ;
Poole-Wilson, PA ;
Coats, AJS .
EUROPEAN HEART JOURNAL, 1999, 20 (09) :683-693
[2]   Cardiac cachexia - A syndrome with impaired survival and immune and neuroendocrine activation [J].
Anker, SD ;
Coats, AJS .
CHEST, 1999, 115 (03) :836-847
[3]  
Anker SD, 1997, CIRCULATION, V96, P526
[4]   Endogenous expression and localization of myostatin and its relation to myosin heavy chain distribution in C2C12 skeletal muscle cells [J].
Artaza, JN ;
Bhasin, S ;
Mallidis, C ;
Taylor, W ;
Ma, K ;
Gonzalez-Cadavid, NF .
JOURNAL OF CELLULAR PHYSIOLOGY, 2002, 190 (02) :170-179
[5]   Organization of the human myostatin gene and expression in healthy men and HIV-infected men with muscle wasting [J].
Gonzalez-Cadavid, NF ;
Taylor, WE ;
Yarasheski, K ;
Sinha-Hikim, I ;
Ma, K ;
Ezzat, S ;
Shen, RQ ;
Lalani, R ;
Asa, S ;
Mamita, M ;
Nair, G ;
Arver, S ;
Bhasin, S .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (25) :14938-14943
[6]   Sarcopenia-consequences, mechanisms; and potential therapies [J].
Greenlund, LJS ;
Nair, KS .
MECHANISMS OF AGEING AND DEVELOPMENT, 2003, 124 (03) :287-299
[7]  
Hemdon DN, 2001, NEW ENGL J MED, V345, P1223
[8]   Regulation of myostatin by glucocorticoids after thermal injury [J].
Lang, CH ;
Silvis, C ;
Nystrom, G ;
Frost, RA .
FASEB JOURNAL, 2001, 15 (08) :1807-+
[9]   ELEVATED CIRCULATING LEVELS OF TUMOR-NECROSIS-FACTOR IN SEVERE CHRONIC HEART-FAILURE [J].
LEVINE, B ;
KALMAN, J ;
MAYER, L ;
FILLIT, HM ;
PACKER, M .
NEW ENGLAND JOURNAL OF MEDICINE, 1990, 323 (04) :236-241
[10]   Characterization of 5′-regulatory region of human myostatin gene:: regulation by dexamethasone in vitro [J].
Ma, K ;
Mallidis, C ;
Artaza, J ;
Taylor, W ;
Gonzalez-Cadavid, N ;
Bhasin, S .
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2001, 281 (06) :E1128-E1136