Modified PNAs: A simple method for the synthesis of monomeric building blocks

被引：37

作者：

Maison, W ^{[1
]}

Schlemminger, I ^{[1
]}

Westerhoff, O ^{[1
]}

Martens, J ^{[1
]}

机构：

[1] Carl von Ossietzky Univ Oldenburg, Fachbereich Chem, D-26111 Oldenburg, Germany

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 04期

关键词：

nucleic acid; DNA; mimetics; peptoids;

D O I：

10.1016/S0960-894X(99)00024-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of PNA-monomers with variations in the substitution pattern using the Ugi-Reaction is described. The one-pot procedure leads to new totally protected PNA-monomers which can be selectively cleaved to N-protected monomeric building blocks for PNA synthesis. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：581 / 584

页数：4

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