Architecture and evolution of organic chemistry

被引：99

作者：

Fialkowski, M

Bishop, KJM

Chubukov, VA

Campbell, CJ

Grzybowski, BA

机构：

[1] Northwestern Univ, Dept Chem & Biol Engn, Evanston, IL 60208 USA

[2] Northwestern Univ, NW Inst Complex, Evanston, IL 60208 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 44期

关键词：

combinatorial chemistry; master equations; networks; organic reactions; stochastic modeling;

D O I：

10.1002/anie.200502272

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) Organic syntheses reported in the literature between 1850 and 2000 are analyzed at the simplified level of a connected network (see the picture of the network for 1850). Fundamental statistical laws that govern organic syntheses are established. These laws allow the estimation of the synthetic and industrial usefulness of organic molecules. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

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页码：7263 / 7269

页数：7

相关论文

共 38 条

[1] Statistical mechanics of complex networks [J].

Albert, R ;

Barabási, AL .

REVIEWS OF MODERN PHYSICS, 2002, 74 (01) :47-97

[2] Internet -: Diameter of the World-Wide Web [J].

Albert, R ;

Jeong, H ;

Barabási, AL .

NATURE, 1999, 401 (6749) :130-131

[3] Rapid evaluation of synthetic and molecular complexity for in silico chemistry [J].

Allu, TK ;

Oprea, TI .

JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2005, 45 (05) :1237-1243

[4] Classes of small-world networks [J].

Amaral, LAN ;

Scala, A ;

Barthélémy, M ;

Stanley, HE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (21) :11149-11152

[5] Complex networks - Augmenting the framework for the study of complex systems [J].

Amaral, LAN ;

Ottino, JM .

EUROPEAN PHYSICAL JOURNAL B, 2004, 38 (02) :147-162

[6]

[Anonymous], ART ORGANIC SYNTHESI

[7] Emergence of scaling in random networks [J].

Barabási, AL ;

Albert, R .

SCIENCE, 1999, 286 (5439) :509-512

[8] Graph structure in the Web [J].

Broder, A ;

Kumar, R ;

Maghoul, F ;

Raghavan, P ;

Rajagopalan, S ;

Stata, R ;

Tomkins, A ;

Wiener, J .

COMPUTER NETWORKS-THE INTERNATIONAL JOURNAL OF COMPUTER AND TELECOMMUNICATIONS NETWORKING, 2000, 33 (1-6) :309-320

[9]

Burke M. D., 2004, ANGEW CHEM, V116, P48

[10] A planning strategy for diversity-oriented synthesis [J].

Burke, MD ;

Schreiber, SL .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2004, 43 (01) :46-58

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