Sialomes and Mialomes: A Systems-Biology View of Tick Tissues and Tick-Host Interactions

被引：89

作者：

Chmelar, Jindrich ^{[1
,2
]}

Kotal, Jan ^{[1
,3
]}

Karim, Shahid ^{[4
]}

Kopacek, Petr ^{[3
]}

Francischetti, Ivo M. B. ^{[5
]}

Pedra, Joao H. F. ^{[6
]}

Kotsyfakis, Michail ^{[3
]}

机构：

[1] Univ South Bohemia Ceske Budejovice, Fac Sci, Budweis, Czech Republic

[2] Tech Univ Dresden, Dept Clin Pathobiochem, Dresden, Germany

[3] Czech Acad Sci, Ctr Biol, Inst Parasitol, Budweis, Czech Republic

[4] Univ Southern Mississippi, Dept Biol Sci, Hattiesburg, MS 39406 USA

[5] NIAID, Sect Vector Biol, Lab Malaria & Vector Res, NIH, Rockville, MD USA

[6] Univ Maryland, Sch Med, Dept Microbiol & Immunol, Baltimore, MD 21201 USA

来源：

TRENDS IN PARASITOLOGY | 2016年 / 32卷 / 03期

基金：

美国国家卫生研究院;

关键词：

RHIPICEPHALUS BOOPHILUS MICROPLUS; SALIVARY-GLAND TRANSCRIPTOME; AMERICAN DOG TICK; IXODES-SCAPULARIS; HARD TICK; CATTLE TICK; ANNOTATED CATALOG; GENE-EXPRESSION; ACARI; SIALOTRANSCRIPTOME;

D O I：

10.1016/j.pt.2015.10.002

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

090105 [作物生产系统与生态工程]; 100103 [病原生物学];

摘要：

Tick saliva facilitates tick feeding and infection of the host. Gene expression analysis of tick salivary glands and other tissues involved in host-pathogen interactions has revealed a wide range of bioactive tick proteins. Transcriptomic analysis has been a milestone in the field and has recently been enhanced by next-generation sequencing (NGS). Furthermore, the application of quantitative proteomics to ticks with unknown genomes has provided deeper insights into the molecular mechanisms underlying tick hematophagy, pathogen transmission, and tick-host-pathogen interactions. We review current knowledge on the transcriptomics and proteomics of tick tissues from a systems-biology perspective and discuss future challenges in the field.

引用

页码：242 / 254

页数：13

共 87 条

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Knockdown of Selenocysteine-Specific Elongation Factor in Amblyomma maculatum Alters the Pathogen Burden of Rickettsia parkeri with Epigenetic Control by the Sin3 Histone Deacetylase Corepressor Complex [J].