Evolution of senescence: Alzheimer's disease and evolution

被引：28

作者：

Charlesworth, B

机构：

[1] Department of Ecology and Evolution, University of Chicago, Chicago

来源：

CURRENT BIOLOGY | 1996年 / 6卷 / 01期

关键词：

D O I：

10.1016/S0960-9822(02)00411-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The genetic basis at Alzheimer's disease is becoming clear; it appears to fit the postulates of the two main theories of the evolution of senescence, with both polymorphic alleles and rare mutations involved.

引用

页码：20 / 22

页数：3

共 14 条

[1] PROTECTIVE EFFECT OF APOLIPOPROTEIN-E TYPE-2 ALLELE FOR LATE-ONSET ALZHEIMER-DISEASE [J].

CORDER, EH ;

SAUNDERS, AM ;

RISCH, NJ ;

STRITTMATTER, WJ ;

SCHMECHEL, DE ;

GASKELL, PC ;

RIMMLER, JB ;

LOCKE, PA ;

CONNEALLY, PM ;

SCHMADER, KE ;

SMALL, GW ;

ROSES, AD ;

HAINES, JL ;

PERICAKVANCE, MA .

NATURE GENETICS, 1994, 7 (02) :180-184

[2] SEGREGATION OF A MISSENSE MUTATION IN THE AMYLOID PRECURSOR PROTEIN GENE WITH FAMILIAL ALZHEIMERS-DISEASE [J].

GOATE, A ;

CHARTIERHARLIN, MC ;

MULLAN, M ;

BROWN, J ;

CRAWFORD, F ;

FIDANI, L ;

GIUFFRA, L ;

HAYNES, A ;

IRVING, N ;

JAMES, L ;

MANT, R ;

NEWTON, P ;

ROOKE, K ;

ROQUES, P ;

TALBOT, C ;

PERICAKVANCE, M ;

ROSES, A ;

WILLIAMSON, R ;

ROSSOR, M ;

OWEN, M ;

HARDY, J .

NATURE, 1991, 349 (6311) :704-706

[3] MOULDING OF SENESCENCE BY NATURAL SELECTION [J].

HAMILTON, WD .

JOURNAL OF THEORETICAL BIOLOGY, 1966, 12 (01) :12-+

[4] A GENETIC-ANALYSIS OF SENESCENCE IN DROSOPHILA [J].

HUGHES, KA ;

CHARLESWORTH, B .

NATURE, 1994, 367 (6458) :64-66

[5]

KREITMAN M, 1991, EVOLUTION MOL LEVEL, P202

[6] CANDIDATE GENE FOR THE CHROMOSOME-1 FAMILIAL ALZHEIMERS-DISEASE LOCUS [J].

LEVYLAHAD, E ;

WASCO, W ;

POORKAJ, P ;

ROMANO, DM ;

OSHIMA, J ;

PETTINGELL, WH ;

YU, CE ;

JONDRO, PD ;

SCHMIDT, SD ;

WANG, K ;

CROWLEY, AC ;

FU, YH ;

GUENETTE, SY ;

GALAS, D ;

NEMENS, E ;

WIJSMAN, EM ;

BIRD, TD ;

SCHELLENBERG, GD ;

TANZI, RE .

SCIENCE, 1995, 269 (5226) :973-977

[7]

MEDAWAR PB, 1952, UNSOLVEED PROBLEM BI

[8] OPTIMALITY, MUTATION AND THE EVOLUTION OF AGING [J].

PARTRIDGE, L ;

BARTON, NH .

NATURE, 1993, 362 (6418) :305-311

[9] FAMILIAL ALZHEIMERS-DISEASE IN KINDREDS WITH MISSENSE MUTATIONS IN A GENE ON CHROMOSOME-1 RELATED TO THE ALZHEIMERS-DISEASE TYPE-3 GENE [J].

ROGAEV, EI ;

SHERRINGTON, R ;

ROGAEVA, EA ;

LEVESQUE, G ;

IKEDA, M ;

LIANG, Y ;

CHI, H ;

LIN, C ;

HOLMAN, K ;

TSUDA, T ;

MAR, L ;

SORBI, S ;

NACMIAS, B ;

PIACENTINI, S ;

AMADUCCI, L ;

CHUMAKOV, I ;

COHEN, D ;

LANNFELT, L ;

FRASER, PE ;

ROMMENS, JM ;

STGEORGEHYSLOP, PH .

NATURE, 1995, 376 (6543) :775-778

[10]

ROSE M.R., 1994, GENETICS EVOLUTION A

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