Total synthesis of natural (+)-lasonolide A

被引：37

作者：

Kang, SH ^{[1
]}

Kang, SY ^{[1
]}

Kim, CM ^{[1
]}

Choi, HW ^{[1
]}

Jun, HS ^{[1
]}

Lee, BM ^{[1
]}

Park, CM ^{[1
]}

Jeong, JW ^{[1
]}

机构：

[1] Korea Adv Inst Sci & Technol, Sch Mol Sci, Ctr Mol Design & Synth, Dept Chem, Taejon 305701, South Korea

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 39期

关键词：

allylation; macrolides; natural products; olefination; total synthesis;

D O I：

10.1002/anie.200352016

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The diastereoselective differentiation of two methylene groups of a cyclic acetal is a unique feature of a highly enantioselective total synthesis of natural (+)-Iasonolide A (see picture), which is used to create the C22 quaternary asymmetric center. Other key strategies are the use of a sulfone-sulfide as a three-carbon fragment with two latent trans double bonds and macrocyclization through an intramolecular Horner-Emmons reaction.

引用

页码：4779 / 4782

页数：4

共 21 条

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[2]

Beck H, 1999, EUR J ORG CHEM, V1999, P2991

[3]

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