Nonsteroidal progesterone receptor antagonists based on a conformationally-restricted subseries of 6-aryl-1,2-dihydro-2,2,4-trimethylquinolines

被引：25

作者：

Hamann, LG

Winn, DT

Pooley, CLF

Tegley, CM

West, SJ

Farmer, LJ

Zhi, L

Edwards, JP

Marschke, KB

Mais, DE

Goldman, ME

Jones, TK

机构：

[1] Ligand Pharmaceut Inc, Dept Med Chem, San Diego, CA 92121 USA

[2] Ligand Pharmaceut Inc, Dept New Leads Discovery, San Diego, CA 92121 USA

[3] Ligand Pharmaceut Inc, Dept Endocrine Res, San Diego, CA 92121 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 19期

关键词：

D O I：

10.1016/S0960-894X(98)00482-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of nonsteroidal human progesterone receptor (hPR) antagonists based on conformationally-restricted analogues of a 6-aryl-1,2-dihydro-2,2,4-trimethylquinoline pharmacophore were synthesized and evaluated for their ability to bind to the human progesterone receptor and inhibit progesterone-stimulated reporter gene expression in mammalian cells, (C) 1998 Elsevier Science Ltd. AU rights reserved.

引用

页码：2731 / 2736

页数：6

共 24 条

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