Identification and Characterization of the First Ovothiol Biosynthetic Enzyme

被引：92

作者：

Braunshausen, Andrea ^{[1
]}

Seebeck, Florian P. ^{[1
]}

机构：

[1] Max Planck Inst Mol Physiol, Phys Biochem Abt, D-44227 Dortmund, Germany

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2011年 / 133卷 / 06期

关键词：

INTERMEDIATE; ACTIVATION; SULFUR; SULFOXIDE; PRODUCTS; THIOL;

D O I：

10.1021/ja109378e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Ovothiols are histidine-derived thiols that were first isolated from marine invertebrates. We have identified a 5-histidylcysteine sulfoxide synthase (OvoA) as the first ovothiol biosynthetic enzyme and characterized OvoAs from Erwinia tasmaniensis and Trypanosoma cruzi. Homologous enzymes are encoded in more than 80 genomes ranging from proteobacteria to animalia.

引用

页码：1757 / 1759

页数：3

共 20 条

[1] Ovothiol and trypanothione as antioxidants in trypanosomatids [J].

Ariyanayagam, MR ;

Fairlamb, AH .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 2001, 115 (02) :189-198

[2] Erwinia tasmaniensis sp nov., a non-phytopathogenic bacterium from apple and pear trees [J].

Geider, Klaus ;

Auling, Georg ;

Du, Zhiqiang ;

Jakovljevic, Vladimir ;

Jock, Susanne ;

Voelksch, Beate .

INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY, 2006, 56 :2937-2943

[3]

HARTMAN PE, 1990, METHOD ENZYMOL, V186, P310

[4] Fe(II)/α-ketoglutarate-dependent hydroxylases and related enzymes [J].

Hausinger, RP .

CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2004, 39 (01) :21-68

[5]

HOLLER TP, 1995, METHOD ENZYMOL, V252, P115

[6]

ISHIKAWA Y, 1974, J BIOL CHEM, V249, P4420

[7] A scent of therapy: pharmacological implications of natural products containing redox-active sulfur atoms [J].

Jacob, Claus .

NATURAL PRODUCT REPORTS, 2006, 23 (06) :851-863

[8] Enzymatic activation of sulfur for incorporation into biomolecules in prokaryotes [J].

Kessler, Dorothea .

FEMS MICROBIOLOGY REVIEWS, 2006, 30 (06) :825-840

[9] The 2-His-1-carboxylate facial triad: a versatile platform for dioxygen activation by mononuclear non-heme iron(II) enzymes [J].

Koehntop, KD ;

Emerson, JP ;

Que, L .

JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, 2005, 10 (02) :87-93

[10] Dithiol proteins as guardians of the intracellular redox milieu in parasites: Old and new drug targets in trypanosomes and malaria-causing plasmodia [J].

Krauth-Siegel, RL ;

Bauer, H ;

Schirmer, H .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2005, 44 (05) :690-715

← 1 2 →