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Effects of repeated exposure to decabrominated diphenyl ether (BDE-209) on mice nervous system and its self repair

被引：30
作者：
Liang, Shu-xuan [1 ]
Gao, Hong-xia [1 ]
Zhao, Yan-yan [2 ]
Ma, Xiao-mei [3 ]
Sun, Han-wen [1 ]
机构：
[1] Hebei Univ, Coll Chem & Environm Sci, Key Lab Analyt Sci & Technol Heibei Prov, Baoding 071002, Peoples R China
[2] Hebei Univ, Ctr Med Expt, Baoding 071002, Peoples R China
[3] Hebei Univ, Dept Neurol, Affiliated Hosp, Baoding 071002, Peoples R China
来源：
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY | 2010年 / 29卷 / 03期
关键词：
Decabrominated diphenyl ether; Neurotoxicity; Acetylcholinesterase; Superoxide dismutase; Malonic dialdehyde; BROMINATED FLAME RETARDANTS; NEONATAL EXPOSURE; SPONTANEOUS BEHAVIOR; PBDE-209; EGGS;
D O I：
10.1016/j.etap.2010.02.005
中图分类号：
X [环境科学、安全科学];
学科分类号：
083001 [环境科学];
摘要：
Decabrominated diphenyl ether (BDE-209) is widely used as brominated flame retardants (BFRs). In order to investigate its direct neurotoxic effects on mice and its self repair, mice were repeatedly exposured to BDE-209. Different concentrations of BDE-209 (0, 0.1, 40, 80 and 160 mg/kg bw/d) were administered daily to CD-1 Swiss mice by gavage for 15,30 and 60 days. Body and brain weights were recorded after the exposure. And the self repair was studied. Levels of acetylcholinesterase (TchE), superoxide dismutase (SOD) and malonic dialdehyde (MDA) in brain were analyzed. Experimental results suggested that the nervous system was permanently damaged by BDE-209 through the cholinergic system enzyme. (C) 2010 Elsevier B.V. All rights reserved.
引用
收藏
页码：297 / 301
页数：5
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