Thiolic antioxidant supplementation of the diet reverses age-related behavioural dysfunction in prematurely ageing mice

被引:11
作者
Guayerbas, N
Puerto, M
Hernanz, A
Miquel, J
De la Fuente, M
机构
[1] Univ Complutense Madrid, Fac Biol, Dept Anim Physiol, E-28040 Madrid, Spain
[2] Hosp Univ La Paz, Dept Biochem, Madrid, Spain
关键词
thioproline; N-acetylcysteine; exploratory activity; neuromuscular coordination; ageing;
D O I
10.1016/j.pbb.2004.10.015
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
We have studied in a model of premature ageing in mice based on their impaired behavioural response in a simple T-maze test the effect of the ingestion of thioproline (TP) plus N-acetylcysteine (NAC) (0.1% w/w of each antioxidant) by female and male mice of Swiss and BALB/c strains on performance in two behaviour tests. The antioxidant treatment (4 weeks in two different periods of life, i.e., adult and old age) protected all animals against early-age-associated behavioural impairment, but this improvement was more evident in the prematurely ageing mice (PAM) in comparison to the control group or non-prematurely ageing mice (NPAM). An improvement of the exploratory activity and neuromuscular coordination after the thiolic antioxidant treatment was found in the PAM, bringing the behavioural parameters to the NPAM levels. These effects could be due to the glutathione precursor role of NAC and TP that replenish the intracellular reduced glutathione (GSH) levels despite advancing age. In conclusion, diet supplementation with thiolic compounds appears to be an effective therapy for protection against early behavioural decline in prematurely ageing mice. (C) 2004 Elsevier Inc. All rights reserved.
引用
收藏
页码:45 / 51
页数:7
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