Locked nucleic acid-nanoparticle conjugates

被引：67

作者：

Seferos, Dwight S.

Giljohann, David A.

Rosi, Nathaniel L.

Mirkin, Chad A.

机构：

[1] Northwestern Univ, Dept Chem, Evanston, IL 60208 USA

[2] Northwestern Univ, Int Inst Nanotechnol, Evanston, IL 60208 USA

来源：

CHEMBIOCHEM | 2007年 / 8卷 / 11期

关键词：

ULTRASENSITIVE DETECTION; CARBON NANOTUBES; DNA; BINDING; POLYNUCLEOTIDES; NANOWIRES; MOLECULES; APOPTOSIS; SURVIVIN; DELIVERY;

D O I：

10.1002/cbic.200700262

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

(Figure Presented) Designer nanoparticle conjugates. Locked nucleic acid (LNA) oligonucleotides can be used to functionalize nanoparticles to yield a novel conjugate that is highly stable and has a remarkably high affinity for complementary nucleic acids. When tested in a cell line model, these conjugates were found to be effective at controlling survivin gene expression. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

收藏

页码：1230 / 1232

页数：3

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