Structure and pharmacology of swelling-sensitive chloride channels, ICl,swell

被引：48

作者：

de Tassigny, AD

Souktani, R

Ghaleh, B

Henry, P

Berdeaux, A

机构：

[1] Fac Med Paris Sud, Pharmacol Lab, INSERM, E00 01, F-94276 Le Kremlin Bicetre, France

[2] Hop Lariboisiere, Serv Cardiol, F-75475 Paris, France

[3] INSERM, U572, F-75475 Paris, France

来源：

FUNDAMENTAL & CLINICAL PHARMACOLOGY | 2003年 / 17卷 / 05期

关键词：

function; modulation; pharmacology; structure; swelling-activated chloride channel;

D O I：

10.1046/j.1472-8206.2003.00197.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Since several years, the interest for chloride channels and more particularly for the enigmatic swelling-activated chloride channel (I-Cl.swell) is increasing. Despite its well-characterized electrophysiological properties, the I-Cl.swell structure and pharmacology. are not totally elucidated. These channels are involved in a variety of cell functions, such as cardiac rhythm, cell proliferation and differentiation, cell volume regulation and cell death through apoptosis. This review will consider different aspects regarding structure, electrophysiological properties, pharmacology, modulation and functions of these swelling-activatcd chloride channels.

引用

收藏

页码：539 / 553

页数：15

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