Vitamin D receptor gene haplotypes and susceptibility to HIV-1 infection in injection drug users

被引：51

作者：

Sanchez de la Torre, Manuel ^{[1
,2
]}

Torres, Carmen ^{[3
]}

Nieto, Gema ^{[1
,2
]}

Vergara, Salvador ^{[5
]}

Carrero, Antonio Jose ^{[4
]}

Macias, Juan ^{[5
]}

Pineda, Juan Antonio ^{[5
]}

Caruz, Antonio ^{[3
]}

Fibla, Joan ^{[1
,2
]}

机构：

[1] Univ Lleida, Dept Ciencies Med Basiques, Fac Med, Human Genet Unit, Lleida 25009, Catalonia, Spain

[2] Inst Recerca Biomed Lleida, Lleida, Spain

[3] Univ Jaen, Fac Sci, Immunogenet Unit, Jaen, Spain

[4] Complejo Hosp Ciudad Jaen, Ctr Provincial Transfus Sanguinea, Jaen, Spain

[5] Hosp Univ Valme, Unidad Clin Enfermedades Infecciosas, Seville, Spain

来源：

JOURNAL OF INFECTIOUS DISEASES | 2008年 / 197卷 / 03期

关键词：

D O I：

10.1086/525043

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Vitamin D receptor (VDR) participates in multiple immune functions. Here, we determined whether VDR gene-sequence variations are associated with intersubject differences in the risk of acquiring human immunodeficiency virus type 1 (HIV-1) infection. We assessed this in 460 males exposed to HIV-1 by injection drug use (335 infected and 125 uninfected) and 124 seronegative healthy subjects. Multilocus logistic regression analysis revealed haplotypes for rs11568820, rs4516035, rs10735810, rs1544410, and rs17878969 polymorphisms showing association with protection to HIV-1 infection (odds ratio, 0.4 [95% confidence interval, 0.22-0.72]; P = .0025), which remained significant after correction for multiple testing. We infer that VDR haplotypes might influence the risk of HIV-1 acquisition.

引用

页码：405 / 410

页数：6

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