Perinatal metabolism of dichlorodiphenyldichloroethylene in Nicaraguan mothers

被引:40
作者
Dorea, JG
Cruz-Granja, AC
Lacayo-Romero, ML
Cuadra-Leal, J
机构
[1] Univ Brasilia, Dept Nutr, BR-70919 Brasilia, DF, Brazil
[2] Univ Brasilia, Dept Chem, BR-70919 Brasilia, DF, Brazil
[3] Univ Auton Nicaragua, CIRA, Managua, Nicaragua
关键词
organochlorine pesticides; breast milk; adipose tissue; fetus; infants;
D O I
10.1006/enrs.2001.4277
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Umbilical cord and venous blood samples were collected at the time of delivery from 52-mothers living in urban and rural areas of the Atoya River basin, Nicaragua. In a subsample of 24 mothers that delivered by Cesarean section, abdominal adipose tissue samples were also collected, as was breast milk later in lactation. Cord and venous blood sera were analyzed for 13 organochlorine pesticides: 1,1,1-trichloro -2,2-bis (4-chlorophenyl) ethane (pp ' -DDT); 1,1-dichloro-2,2-bis (pchlorophenyl)ethylene (pp ' -DDE); pp ' -dichlorophenyldichloro diene (pp ' -DDD); alpha -hexachlorocyclohexane (alpha -HCH); beta -hexachlorocyclohexane (B-HCH); gamma -hexachlorocyclohexane (gamma -HCH); delta -hexachlorocyclohexane (delta -HCH); toxaphene; dieldrin; endrin; aldrin; heptachlor; and heptachlor epoxide. In venous blood only pp ' -DDE (100% of samples), pp ' -DDT (1.92%), dieldrin (15.38%), heptachlor (15.38%), gamma -HCH (7.69%), beta -HCH (11.53%), and delta -HCH (1.92%) were found, whereas in cord blood only pp ' -DDE (100%), pp ' -DDT (3.84%), dieldrin (19.23%), and heptachlor (9.16%), were found. The persistent DDT metabolite pp ' -DDE, present in all samples of blood serum, adipose tissue, and breast milk, was studied in relation to maternal characteristics such as body mass index (BMI), age, lactation experience, and fetal pesticide acquisition. Mean venous (7.12 mug/g) and cord (6.39 mug/g) pp ' -DDE concentrations were not significantly different but were significantly correlated. pp ' -DDE in maternal adipose tissue was positively correlated with pp ' -DDE in cord blood (P = 0.0001) and breast milk (P < 0.0001) and marginally correlated with changes in BMI (r = -0.03088; P = 0.06). There was a higher proportion of samples (58%) with a greater concentration of DDE in venous than in cord blood. Although DDE accumulation may be less during fetal development than during breast feeding, exposure during embryogenesis may be more important than during the postnatal period. (C) 2001 Academic Press.
引用
收藏
页码:229 / 237
页数:9
相关论文
共 63 条
[1]   ORGANOCHLORINE RESIDUES IN MATERNAL BLUBBER, MILK, AND PUP BLUBBER FROM GREY SEALS (HALICHOERUS-GRYPUS) FROM SABLE-ISLAND, NOVA-SCOTIA [J].
ADDISON, RF ;
BRODIE, PF .
JOURNAL OF THE FISHERIES RESEARCH BOARD OF CANADA, 1977, 34 (07) :937-941
[2]  
Amarowicz R, 1993, Rocz Panstw Zakl Hig, V44, P379
[3]   STUDIES ON THE EFFECT OF DIETARY-PROTEIN AND FAT-CONTENT UPON DDT METABOLISM IN RAT-LIVER [J].
ANDO, M .
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH, 1982, 10 (01) :11-22
[4]  
ARBUCKLE TE, 1998, CRIT VER TOXICOL, V7, P489
[5]  
ArchibequeEngle SL, 1997, J TOXICOL ENV HEALTH, V52, P285, DOI 10.1080/009841097159584
[6]   Balancing risks on the backs of the poor [J].
Attaran, A ;
Roberts, DR ;
Curtis, CF ;
Kilama, WL .
NATURE MEDICINE, 2000, 6 (07) :729-+
[7]   CONCENTRATION OF DDT AND DDE IN PLASMA AND SUBCUTANEOUS ADIPOSE-TISSUE BEFORE AND AFTER INTESTINAL-BYPASS OPERATION FOR TREATMENT OF OBESITY [J].
BACKMAN, L ;
KOLMODINHEDMAN, B .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 1978, 46 (03) :663-669
[8]  
Baris D, 2000, CANCER EPIDEM BIOMAR, V9, P193
[9]  
BEAUFRAND M-J, 1978, Toxicological European Research, V1, P39
[10]   Organochlorines and heavy metals in pregnant women from the Disko Bay area in Greenland [J].
Bjerregaard, P ;
Hansen, JC .
SCIENCE OF THE TOTAL ENVIRONMENT, 2000, 245 (1-3) :195-202