The transcriptional program in the response of human fibroblasts to serum

被引：1576

作者：

Iyer, VR

Eisen, MB

Ross, DT

Schuler, G

Moore, T

Lee, JCF

Trent, JM

Staudt, LM

Hudson, J

Boguski, MS

Lashkari, D

Shalon, D

Botstein, D

Brown, PO ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Dept Biochem, Stanford, CA 94305 USA

[2] Stanford Univ, Sch Med, Dept Genet, Stanford, CA 94305 USA

[3] Natl Lib Med, Natl Ctr Biotechnol Informat, Bethesda, MD 20894 USA

[4] Res Genet Inc, Huntsville, AL 35801 USA

[5] Incyte Pharmaceut, Fremont, CA 94555 USA

[6] Natl Human Genome Res Inst, Canc Genet Lab, NIH, Bethesda, MD 20892 USA

[7] NCI, Metab Branch, Div Clin Sci, Bethesda, MD 20892 USA

[8] Stanford Univ, Sch Med, Howard Hughes Med Inst, Stanford, CA 94305 USA

来源：

SCIENCE | 1999年 / 283卷 / 5398期

关键词：

D O I：

10.1126/science.283.5398.83

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The temporal program of gene expression during a model physiological response of human cells, the response of fibroblasts to serum, was explored with a complementary DNA microarray representing about 8600 different human genes. Genes could be clustered into groups on the basis of their temporal patterns of expression in this program. Many features of the transcriptional program appeared to be related to the physiology of wound repair, suggesting that fibroblasts play a larger and richer role in this complex multicellular response than had previously been appreciated.

引用

页码：83 / 87

页数：5

共 15 条

[1] ESTABLISHING A HUMAN TRANSCRIPT MAP
BOGUSKI, MS
SCHULER, GD
[J]. NATURE GENETICS, 1995, 10 (04) : 369 - 371
[2] A NOVEL HUMAN CDNA HIGHLY HOMOLOGOUS TO THE FISH HORMONE STANNIOCALCIN
CHANG, ACM
JANOSI, J
HULSBEEK, M
DEJONG, D
JEFFREY, KJ
NOBLE, JR
REDDEL, RR
[J]. MOLECULAR AND CELLULAR ENDOCRINOLOGY, 1995, 112 (02) : 241 - 247
[3] DeRisi J, 1996, NAT GENET, V14, P457
[4] Exploring the metabolic and genetic control of gene expression on a genomic scale
DeRisi, JL
Iyer, VR
Brown, PO
[J]. SCIENCE, 1997, 278 (5338) : 680 - 686
[5] Cluster analysis and display of genome-wide expression patterns
Eisen, MB
Spellman, PT
Brown, PO
Botstein, D
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (25) : 14863 - 14868
[6] PROTEIN-KINASES AND PHOSPHATASES - THE YIN AND YANG OF PROTEIN-PHOSPHORYLATION AND SIGNALING
HUNTER, T
[J]. CELL, 1995, 80 (02) : 225 - 236
[7] KREK W, 1995, METHOD ENZYMOL, V254, P114
[8] The IMAGE consortium: An integrated molecular analysis of genomes and their expression
Lennon, G
Auffray, C
Polymeropoulos, M
Soares, MB
[J]. GENOMICS, 1996, 33 (01) : 151 - 152
[9] ENDOTHELIN PEPTIDES - BIOLOGICAL-ACTIVITIES, CELLULAR SIGNALING AND CLINICAL-SIGNIFICANCE
LEPPALUOTO, J
RUSKOAHO, H
[J]. ANNALS OF MEDICINE, 1992, 24 (03) : 153 - 161
[10] LIVAK KJ, 1995, PCR METH APPL, V4, P357

← 1 2 →