Chiral binaphthyl-derived amine-thiourea organocatalyst-promoted asymmetric Morita-Baylis-Hillman reaction

被引:260
作者
Wang, J
Li, H
Yu, XH
Zu, LS
Wang, W [1 ]
机构
[1] Univ New Mexico, Dept Chem, Albuquerque, NM 87131 USA
[2] E China Univ Sci & Technol, Coll Pharmaceut Engn, Dept Med Chem, Shanghai 200237, Peoples R China
关键词
D O I
10.1021/ol051822+
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A new bifunctional binaphthyl-derived amine thiourea organocatalyst has been developed to promote enantioselective Morita-Baylis-Hillman reaction of cyclohexenone with a wide range of aldehydes. The process, catalyzed by the amine thiourea, affords synthetically valuable chiral allylic alcohol building blocks in high yields and high enantioselectivities.
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页码:4293 / 4296
页数:4
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