Pharmacology of MDMA in humans

被引:119
作者
de la Torre, R
Farré, M
Roset, PN
López, CH
Mas, M
Ortuno, J
Menoyo, E
Pizarro, N
Segura, J
Cami, J
机构
[1] Univ Autonoma Barcelona, Inst Municipal Invest Med, Pharmacol Unit, E-08003 Barcelona, Spain
[2] Univ Pompeu Fabra, Barcelona, Spain
来源
NEUROBIOLOGICAL MECHANISMS OF DRUGS OF ABUSE: COCAINE, IBOGAINE, AND SUBSTITUTED AMPHETAMINES | 2000年 / 914卷
关键词
D O I
10.1111/j.1749-6632.2000.tb05199.x
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
MDMA given at recreational doses (range tested 50 to 150 mg) to healthy volunteers, produced mydriasis and marked increases in systolic and diastolic blood pressure, heart rate, and pupillary diameter. MDMA induced changes on oral temperature. The time course of this observation was biphasic, as a slight decrease at 1 h and a slight increase at 2 and 4 h were observed. MDMA induced a slight dose-dependent impairment on psychomotor performance. MFMA produced a marked rise in plasma cortisol and prolactin concentrations. The elimination half-life of MDMA was about 8-9 h. Drug concentrations increased, and a parallel increase in physiologic and hormonal measures was observed. Both peak concentrations and peak effects were obtained between 1 and 2 h and decreased to baseline values 4-6 h after drug administration.
引用
收藏
页码:225 / 237
页数:13
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