KLF4, p21 and context-dependent opposing forces in cancer

被引：448

作者：

Rowland, BD ^{[1
]}

Peeper, DS ^{[1
]}

机构：

[1] Netherlands Canc Inst, Div Mol Genet, NL-1066 CX Amsterdam, Netherlands

来源：

NATURE REVIEWS CANCER | 2006年 / 6卷 / 01期

关键词：

D O I：

10.1038/nrc1780

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Kruppel- like factors are transcriptional regulators that influence several cellular functions, including proliferation. Recent studies have shown that one family member, KLF4, can function both as a tumour suppressor and an oncogene. The ability of KLF4 to affect the levels of expression of the cell- cycle regulator p21 seems to be involved, in that this protein might function as a switch that determines the outcome of KLF4 signalling. Is this role of p21 restricted to KLF4, or does p21 represent a nodal point for signals from multiple other factors with opposing functions in cancer?

引用

页码：11 / 23

页数：13

共 208 条

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