Relationship between magnitude of hypothermia during ischemia and preventive effect against post-ischemic DNA fragmentation in the gerbil hippocampus

被引：27

作者：

Niwa, M

Hara, A

Iwai, T

Nakashima, M

Yano, H

Yoshimi, N

Mori, H

Uematsu, T

机构：

[1] Gifu Univ, Sch Med, Dept Pharmacol, Gifu 5008705, Japan

[2] Gifu Univ, Sch Med, Dept Pathol, Gifu 5008705, Japan

[3] Gifu Univ, Sch Med, Dept Neurosurg, Gifu 5008705, Japan

[4] Asahi Univ, Murakami Mem Hosp, Dept Neurosurg, Gifu 5008856, Japan

来源：

BRAIN RESEARCH | 1998年 / 794卷 / 02期

关键词：

hypothermia; delayed neuronal death; gerbil; forebrain ischemia; DNA fragmentation;

D O I：

10.1016/S0006-8993(98)00324-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Protective effect of hypothermia against DNA fragmentation in hippocampal CA1 field after transient forebrain ischemia in gerbils was evaluated by changing the magnitude of hypothermia. Inhibition of DNA fragmentation was proportional to the magnitude of hypothermia. The result indicates that, in terms of susceptibility to ischemia, hippocampal CA1 neurons are sensitive to a relatively small decrement of temperature, with temperatures less than or equal to 35 degrees C being critical for the prevention of apoptotic process following transient forebrain ischemia. (C) 1998 Elsevier Science B.V. All rights reserved.

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收藏

页码：338 / 342

页数：5

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