Cerebral blood flow relationships associated with a difficult tone recognition task in trained normal volunteers

被引:54
作者
Holcomb, HH
Medoff, DR
Caudill, PJ
Zhao, Z
Lahti, AC
Dannals, RF
Tamminga, CA
机构
[1] Maryland Psychiat Res Ctr, Baltimore, MD 21228 USA
[2] Univ Maryland, Dept Psychiat, College Pk, MD 20742 USA
[3] Johns Hopkins Med Inst, Dept Radiol, Div Nucl Med, Baltimore, MD 21205 USA
关键词
D O I
10.1093/cercor/8.6.534
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Tone recognition is partially subserved by neural activity in the right frontal and primary auditory cortices. First we determined the brain areas associated with tone perception and recognition. This study then examined how regional cerebral blood flow (rCBF) in these and other brain regions correlates with the behavioral characteristics of a difficult tone recognition task. rCBF changes were assessed using (H2O)-O-15 Positron emission tomography. Subtraction procedures were used to localize significant change regions and correlational analyses were applied to determine how response times (RT) predicted rCBF patterns. Twelve trained normal volunteers were studied in three conditions: REST, sensory motor control (SMC) and decision (DEC). The SMC-REST contrast revealed bilateral activation of primary auditory cortices, cerebellum and bilateral inferior frontal gyri. DEC-SMC produced significant clusters in the right middle and inferior frontal gyri, insula and claustrum; the anterior cingulate gyrus and supplementary motor area; the left insula/claustrum; and the left cerebellum. Correlational analyses, RT versus rCBF from DEC scans, showed a positive correlation in right inferior and middle frontal cortex; rCBF in bilateral auditory cortices and cerebellum exhibited significant negative correlations with RT. These changes suggest that neural activity in the right frontal, superior temporal and cerebellar regions shifts hack and forth in magnitude depending on whether tone recognition RT is relatively fast or slow, during a difficult, accurate assessment.
引用
收藏
页码:534 / 542
页数:9
相关论文
共 75 条
[1]  
BUCKNER RL, 1995, J NEUROSCI, V15, P12
[2]   DISSOCIATION OF HUMAN PREFRONTAL CORTICAL AREAS ACROSS DIFFERENT SPEECH PRODUCTION TASKS AND GENDER GROUPS [J].
BUCKNER, RL ;
RAICHLE, ME ;
PETERSEN, SE .
JOURNAL OF NEUROPHYSIOLOGY, 1995, 74 (05) :2163-2173
[3]  
COHEN RM, 1992, EXP BRAIN RES, V92, P165
[4]  
Colombo M, 1996, J NEUROSCI, V16, P4501
[5]   AUDITORY ASSOCIATION CORTEX LESIONS IMPAIR AUDITORY SHORT-TERM-MEMORY IN MONKEYS [J].
COLOMBO, M ;
DAMATO, MR ;
RODMAN, HR ;
GROSS, CG .
SCIENCE, 1990, 247 (4940) :336-338
[6]  
COURCHESNE E, 1991, PEDIATRICS, V87, P781
[7]   THE ANATOMY OF PHONOLOGICAL AND SEMANTIC PROCESSING IN NORMAL SUBJECTS [J].
DEMONET, JF ;
CHOLLET, F ;
RAMSAY, S ;
CARDEBAT, D ;
NESPOULOUS, JL ;
WISE, R ;
RASCOL, A ;
FRACKOWIAK, R .
BRAIN, 1992, 115 :1753-1768
[8]   THE NEURAL BASIS OF THE CENTRAL EXECUTIVE SYSTEM OF WORKING-MEMORY [J].
DESPOSITO, M ;
DETRE, JA ;
ALSOP, DC ;
SHIN, RK ;
ATLAS, S ;
GROSSMAN, M .
NATURE, 1995, 378 (6554) :279-281
[9]   DISRUPTIONS OF AUDITORY SEQUENCE DISCRIMINATION BY UNILATERAL AND BILATERAL CORTICAL ABLATIONS OF SUPERIOR TEMPORAL GYRUS IN MONKEY [J].
DEWSON, JH ;
COWEY, A ;
WEISKRANTZ, L .
EXPERIMENTAL NEUROLOGY, 1970, 28 (03) :529-+
[10]   BLOOD-FLOW CHANGES IN HUMAN SOMATOSENSORY CORTEX DURING ANTICIPATED STIMULATION [J].
DREVETS, WC ;
BURTON, H ;
VIDEEN, TO ;
SNYDER, AZ ;
SIMPSON, JR ;
RAICHLE, ME .
NATURE, 1995, 373 (6511) :249-252