The premature ageing syndrome protein, WRN, is a 3′→5′ exonuclease

被引:352
作者
Huang, SR
Li, BM
Gray, MD
Oshima, J
Mian, SI
Campisi, J [1 ]
机构
[1] Univ Calif Berkeley, Lawrence Berkeley Lab, Div Cell & Mol Biol, Berkeley, CA 94720 USA
[2] Univ Washington, Dept Pathol, Seattle, WA 98195 USA
[3] Univ Calif Berkeley, Lawrence Berkeley Lab, Dept Radiat Biol, Berkeley, CA 94720 USA
关键词
D O I
10.1038/2410
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
引用
收藏
页码:114 / 116
页数:3
相关论文
共 14 条
  • [1] HOMOLOGOUS RECOMBINATION IS ELEVATED IN SOME WERNER-LIKE SYNDROMES BUT NOT DURING NORMAL INVITRO OR INVIVO SENESCENCE OF MAMMALIAN-CELLS
    CHENG, RZ
    MURANO, S
    KURZ, B
    REIS, RJS
    [J]. MUTATION RESEARCH, 1990, 237 (5-6): : 259 - 269
  • [2] MUTATOR PHENOTYPE OF WERNER SYNDROME IS CHARACTERIZED BY EXTENSIVE DELETIONS
    FUKUCHI, K
    MARTIN, GM
    MONNAT, RJ
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (15) : 5893 - 5897
  • [3] BLOOM-SYNDROME - A MENDELIAN PROTOTYPE OF SOMATIC MUTATIONAL DISEASE
    GERMAN, J
    [J]. MEDICINE, 1993, 72 (06) : 393 - 406
  • [4] Hierarchical deterioration of body systems in Werner's syndrome: Implications for normal ageing
    Goto, M
    [J]. MECHANISMS OF AGEING AND DEVELOPMENT, 1997, 98 (03) : 239 - 254
  • [5] The Werner syndrome protein is a DNA helicase
    Gray, MD
    Shen, JC
    KamathLoeb, AS
    Blank, A
    Sopher, BL
    Martin, GM
    Oshima, J
    Loeb, LA
    [J]. NATURE GENETICS, 1997, 17 (01) : 100 - 103
  • [6] MAIN IS, 1997, NUCLEIC ACIDS RES, V25, P3187
  • [7] Martin G M, 1978, Birth Defects Orig Artic Ser, V14, P5
  • [8] MARTIN GM, 1970, LAB INVEST, V23, P86
  • [9] Positionally cloned human disease genes: Patterns of evolutionary conservation and functional motifs
    Mushegian, AR
    Bassett, DE
    Boguski, MS
    Bork, P
    Koonin, EV
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (11) : 5831 - 5836
  • [10] An apoptosis-inducing genotoxin differentiates heterozygotic carriers for Werner helicase mutations from wild-type and homozygous mutants
    Ogburn, CE
    Oshima, J
    Poot, M
    Chen, R
    Gollahon, KA
    Rabinovitch, PS
    Martin, GM
    [J]. HUMAN GENETICS, 1997, 101 (02) : 121 - 125