Spinal cord injury therapies in humans: an overview of current clinical trials and their potential effects on intrinsic CNS macrophages

被引：81

作者：

Gensel, John C. ^{[1
]}

Donnelly, Dustin J. ^{[1
]}

Popovich, Phillip G. ^{[1
]}

机构：

[1] Ohio State Univ, Coll Med, Ctr Brain & Spinal Cord Repair, Columbus, OH 43210 USA

来源：

EXPERT OPINION ON THERAPEUTIC TARGETS | 2011年 / 15卷 / 04期

关键词：

macrophage; microglia; neuroinflammation; neurotrauma; spinal cord injury; HIGH-DOSE METHYLPREDNISOLONE; SODIUM-CHANNEL BLOCKERS; OLFACTORY ENSHEATHING CELLS; MESENCHYMAL STROMAL CELLS; FUNCTIONAL RECOVERY; AXONAL REGENERATION; SECONDARY INJURY; STEM-CELLS; INFLAMMATORY RESPONSE; STEM/PROGENITOR CELLS;

D O I：

10.1517/14728222.2011.553605

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Areas covered: This review provides a comprehensive overview of current SCI clinical trials that are intended to promote neuroprotection, axon regeneration or cell replacement. None of these potential therapies were developed with the goal of influencing macrophage function; however, it is likely that each will have direct or indirect effects on CNS macrophages. The potential impact of each trial is discussed in the context of CNS macrophage biology. Expert opinion: Activation of CNS macrophages is an inevitable consequence of traumatic SCI. Given that these cells are exquisitely sensitive to changes in microenvironment, any intervention that affects tissue integrity and/or the composition of the cellular milieu will undoubtedly affect CNS macrophages. Thus, it is important to understand how current clinical trials will affect intrinsic CNS macrophages.

引用

页码：505 / 518

页数：14

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