Genome-wide association analysis identifies three psoriasis susceptibility loci

被引：253

作者：

Stuart, Philip E. ^{[1
]}

Nair, Rajan P. ^{[1
]}

Ellinghaus, Eva ^{[2
]}

Ding, Jun ^{[3
]}

Tejasvi, Trilokraj ^{[1
]}

Gudjonsson, Johann E. ^{[1
]}

Li, Yun ^{[3
]}

Weidinger, Stephan ^{[4
]}

Eberlein, Bernadette ^{[4
]}

Gieger, Christian ^{[5
]}

Wichmann, H. Erich ^{[5
]}

Kunz, Manfred ^{[6
]}

Ike, Robert ^{[7
]}

Krueger, Gerald G. ^{[8
]}

Bowcock, Anne M. ^{[9
]}

Mrowietz, Ulrich ^{[10
]}

Lim, Henry W. ^{[11
]}

Voorhees, John J. ^{[1
]}

Abecasis, Goncalo R. ^{[3
]}

Weichenthal, Michael ^{[10
]}

Franke, Andre ^{[2
]}

Rahman, Proton ^{[12
]}

Gladman, Dafna D. ^{[13
]}

Elder, James T. ^{[1
,14
]}

机构：

[1] Univ Michigan, Sch Med, Dept Dermatol, Ann Arbor, MI 48109 USA

[2] Univ Kiel, Inst Clin Mol Biol, Kiel, Germany

[3] Univ Michigan, Sch Publ Hlth, Dept Biostat, Ctr Stat Genet, Ann Arbor, MI 48109 USA

[4] Tech Univ Munich, Dept Dermatol & Allergy, Munich, Germany

[5] Univ Munich, Inst Med Informat Biometry & Epidemiol, Munich, Germany

[6] Univ Lubeck, Comprehens Ctr Inflammat Med, Lubeck, Germany

[7] Univ Michigan, Sch Med, Dept Med, Ann Arbor, MI 48104 USA

[8] Univ Utah, Dept Dermatol, Salt Lake City, UT USA

[9] Washington Univ, Dept Genet, Div Human Genet, St Louis, MO 63110 USA

[10] Univ Kiel, Dept Dermatol, D-2300 Kiel, Germany

[11] Henry Ford Hosp, Dept Dermatol, Detroit, MI 48202 USA

[12] Mem Univ Newfoundland, Dept Med, St John, NF, Canada

[13] Univ Toronto, Dept Rheumatol, Toronto, ON, Canada

[14] Ann Arbor Vet Affairs Med Ctr, Ann Arbor, MI USA

来源：

NATURE GENETICS | 2010年 / 42卷 / 11期

基金：

加拿大健康研究院; 美国国家卫生研究院;

关键词：

NF-KAPPA-B; EXPRESSION; ARTHRITIS; MAP;

D O I：

10.1038/ng.693

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We carried out a meta-analysis of two recent psoriasis genome-wide association studies(1,2) with a combined discovery sample of 1,831 affected individuals (cases) and 2,546 controls. One hundred and two loci selected based on P value rankings were followed up in a three-stage replication study including 4,064 cases and 4,685 controls from Michigan, Toronto, Newfoundland and Germany. In the combined meta-analysis, we identified three new susceptibility loci, including one at NOS2 (rs4795067, combined P = 4 x 10(-11)), one at FBXL19 (rs10782001, combined P = 9 x 10(-10)) and one near PSMA6-NFKBIA (rs12586317, combined P = 2 x 10(-8)). All three loci were also associated with psoriatic arthritis (rs4795067, combined P = 1 x 10(-5); rs10782001, combined P = 4 x 10-8; and rs12586317, combined P = 6 x 10-5) and purely cutaneous psoriasis (rs4795067, combined P = 1 x 10-8; rs10782001, combined P = 2 x 10(-6); and rs12586317, combined P = 1 x 10-6). We also replicated a recently identified(3) association signal near RNF114 (rs495337, combined P = 2 x 10(-7)).

引用

页码：1000 / U125

页数：7

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