Active efflux of norfloxacin by Bacteroides fragilis

被引：49

作者：

Miyamae, S

Nikaido, H

Tanaka, Y

Yoshimura, F

机构：

[1] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA

[2] Aichi Gakuin Univ, Sch Dent, Dept Microbiol, Nagoya, Aichi 4648650, Japan

[3] Aichi Gakuin Univ, Sch Dent, Dept Prosthodont 1, Nagoya, Aichi 4648650, Japan

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1998年 / 42卷 / 08期

关键词：

D O I：

10.1128/AAC.42.8.2119

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Norfloxacin was actively pumped out by Bacteroides fragilis, which is intrinsically resistant to most fluoroquinolones. Reserpine moderately inhibited the efflux. A one-step spontaneous mutant had increased resistance to norfloxacin, ethidium bromide, and puromycin, a result suggesting that the efflux is catalyzed by a multidrug pump with specificity similar to that of NorA/Bmr.

引用

收藏

页码：2119 / 2121

页数：3

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