Viral and developmental cell fusion mechanisms: Conservation and divergence

被引:95
作者
Sapir, Amir [1 ]
Avinoam, Ori [1 ]
Podbilewicz, Benjamin [1 ]
Chernomordik, Leonid V. [2 ]
机构
[1] Technion Israel Inst Technol, Dept Biol, IL-32000 Haifa, Israel
[2] NICHHD, Sect Membrane Biol, Lab Cellular & Mol Biophys, NIH, Bethesda, MD 20892 USA
关键词
D O I
10.1016/j.devcel.2007.12.008
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Membrane fusion is a fundamental requirement in numerous developmental, physiological, and pathological processes in eukaryotes. So far, only a limited number of viral and cellular fusogens, proteins that fuse membranes, have been isolated and characterized. Despite the diversity in structures and functions of known fusogens, some common principles of action apply to all fusion reactions. These can serve as guidelines in the search for new fusogens, and may allow the formulation of a cross-species, unified theory to explain divergent and convergent evolutionary principles of membrane fusion.
引用
收藏
页码:11 / 21
页数:11
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