Return to homeostasis: downregulation of NF-κB responses

被引：285

作者：

Ruland, Juergen ^{[1
,2
]}

机构：

[1] Tech Univ Munich, Klinikum Rechts Isar, Inst Mol Immunol, D-8000 Munich, Germany

[2] German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Lab Signaling Immune Syst, Neuherberg, Germany

来源：

NATURE IMMUNOLOGY | 2011年 / 12卷 / 08期

关键词：

T-CELL-ACTIVATION; ALPHA-MEDIATED PHOSPHORYLATION; NEGATIVE FEEDBACK LOOP; EDITING ENZYME A20; IKK-ALPHA; IRAK-M; DEUBIQUITINATING ENZYME; GENE-EXPRESSION; INNATE IMMUNITY; SIGNALING PATHWAY;

D O I：

10.1038/ni.2055

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Activation of NF-kappa B transcription factors by receptors of the innate or adaptive immune system is essential for host defense. However, after danger is eliminated, NF-kappa B signaling needs to be tightly downregulated for the maintenance of tissue homeostasis. This review highlights key negative regulatory principles that affect the amount, localization or conformational properties of NF-kappa B-activating proteins to attenuate the NF-kappa B response. These mechanisms are needed to prevent inflammation, autoimmune disease and oncogenesis.

引用

页码：709 / 714

页数：6

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