The golden root, Rhodiola rosea, prolongs lifespan but decreases oxidative stress resistance in yeast Saccharomyces cerevisiae

被引：40

作者：

Bayliak, Maria M. ^{[1
]}

Lushchak, Volodymyr I. ^{[1
]}

机构：

[1] Vassyl Stefanyk Precarpathian Natl Univ, Dept Biochem & Biotechnol, UA-76025 Ivano Frankivsk, Ukraine

来源：

PHYTOMEDICINE | 2011年 / 18卷 / 14期

关键词：

Saccharomyces cerevisiae; Rhodiola rosea; Lifespan; Hydrogen peroxide; Antioxidant enzymes; SUPEROXIDE-DISMUTASE;

D O I：

10.1016/j.phymed.2011.06.010

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

The effect of aqueous extract from R. rosea root on lifespan and the activity of antioxidant enzymes in budding yeast Saccharomyces cerevisiae have been studied. The supplementation of the growth medium with R. rosea extract decreased survival of exponentially growing S. cerevisiae cells under H2O2-induced oxidative stress, but increased viability and reproduction success of yeast cells in stationary phase. The extract did not significantly affect catalase activity and decreased SOD activity in chronologically aged yeast population. These results suggest that R. rosea acts as a stressor for S. cerevisiae cells, what sensitizes yeast cells to oxidative stress at exponential phase, but induces adaptation in stationary phase cells demonstrating the positive effect on yeast survival without activation of major antioxidant enzymes. (C) 2011 Elsevier GmbH. All rights reserved.

引用

页码：1262 / 1268

页数：7

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