Pharmacokinetic interactions of nevirapine and methadone and guidelines for use of nevirapine to treat injection drug users

被引：72

作者：

Clarke, SM

Mulcahy, FM

Tjia, J

Reynolds, HE

Gibbons, SE

Barry, MG

Back, DJ

机构：

[1] St James Hosp, GUIDE Clin, Dept Genitourinary Med, Dublin 8, Ireland

[2] St James Hosp, Dept Pharmacoecon, Dublin 8, Ireland

[3] Univ Liverpool, Dept Pharmacol & Therapeut, Liverpool L69 3BX, Merseyside, England

来源：

CLINICAL INFECTIOUS DISEASES | 2001年 / 33卷 / 09期

关键词：

D O I：

10.1086/322519

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Administration of nevirapine to HIV-infected injection drug users who also receive methadone results in a significant reduction in methadone exposure after 7-10 days of therapy. Many patients require an increase in methadone dose to counteract this effect.

引用

页码：1595 / 1597

页数：3

共 12 条

[1] Nevirapine induced opiate withdrawal among injection drug users with HIV infection receiving methadone
Altice, FL
Friedland, GH
Cooney, EL
[J]. AIDS, 1999, 13 (08) : 957 - 962
[2] ENZYME-INDUCTION AND INHIBITION
BARRY, M
FEELY, J
[J]. PHARMACOLOGY & THERAPEUTICS, 1990, 48 (01) : 71 - 94
[3] The pharmacokinetics of methadone in HIV-positive patients receiving the non-nucleoside reverse transcriptase inhibitor efavirenz
Clarke, SM
Mulcahy, FM
Tjia, J
Reynolds, HE
Gibbons, SE
Barry, MG
Back, DJ
[J]. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2001, 51 (03) : 213 - 217
[4] The effect of fluconazole on the clinical pharmacokinetics of methadone
Cobb, MN
Desai, J
Brown, LS
Zannikos, PN
Rainey, PM
[J]. CLINICAL PHARMACOLOGY & THERAPEUTICS, 1998, 63 (06) : 655 - 662
[5] OPIOID TOXICITY - METHADONE - ONE PERSONS MAINTENANCE DOSE IS ANOTHERS POISON
HARDINGPINK, D
[J]. LANCET, 1993, 341 (8846) : 665 - 666
[6] Methadone withdrawal when starting an antiretroviral regimen including nevirapine
Heelon, MW
Meade, LB
[J]. PHARMACOTHERAPY, 1999, 19 (04): : 471 - 472
[7] Involvement of cytochrome P450 3A4 enzyme in the N-demethylation of methadone in human liver microsomes
Iribarne, C
Berthou, F
Baird, S
Dreano, Y
Picart, D
Bail, JP
Beaune, P
Menez, JF
[J]. CHEMICAL RESEARCH IN TOXICOLOGY, 1996, 9 (02) : 365 - 373
[8] RIFAMPIN-INDUCED METHADONE WITHDRAWAL
KREEK, MJ
GARFIELD, JW
GUTJAHR, CL
GIUSTI, LM
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1976, 294 (20) : 1104 - 1106
[9] Nevirapine-induced withdrawal symptoms in HIV patients on methadone maintenance programme:: an alert
Otero, MJ
Fuertes, A
Sánchez, R
Luna, G
[J]. AIDS, 1999, 13 (08) : 1004 - 1005
[10] Staszewski S, 1998, ANTIVIR THER, V3, P55

← 1 2 →