Hedgehog signaling: A tale of two lipids

被引：71

作者：

Ingham, PW ^{[1
]}

机构：

[1] Univ Sheffield, Sch Med & Biomed Sci, Ctr Dev Genet, MRC,Intercellular Signalling Grp, Sheffield S10 2TN, S Yorkshire, England

来源：

SCIENCE | 2001年 / 294卷 / 5548期

关键词：

D O I：

10.1126/science.1064115

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Hedgehog proteins constitute one of the major classes of intercellular signals that control inductive interactions during animal development. These proteins undergo unusual lipid modifications and signal through an unconventional transmembrane protein receptor that is characterized by a sequence motif implicated in sterol sensing. Recent studies suggest that the lipid adducts regulate the range and potency of the signals, whereas the sterol-sensing domain is essential for receptor activity.

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页码：1879 / 1881

页数：3

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