Imatinib induces autophagy through BECLIN-1 and ATG5 genes in chronic myeloid leukemia cells

被引：50

作者：

Can, Geylani ^{[1
]}

Ekiz, Huseyin Atakan ^{[1
]}

Baran, Yusuf ^{[1
]}

机构：

[1] Izmir Inst Technol, Fac Sci, Dept Mol Biol & Genet, TR-35430 Izmir, Turkey

来源：

HEMATOLOGY | 2011年 / 16卷 / 02期

关键词：

Chronic myeloid leukemia; Imatinib; Autophagy; ATG genes; KINASE INHIBITOR IMATINIB; INDUCED APOPTOSIS; CANCER-CELLS; MESYLATE; MACROAUTOPHAGY; ORGANIZATION; PRINCIPLES; RESISTANCE; HEALTH; DEATH;

D O I：

10.1179/102453311X12902908412039

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Imatinib is a chemotherapeutic drug used for the treatment of chronic myeloid leukemia (CML). Recent data showed imatinib-induced cell death in various types of cancers. Autophagy is the physiological process in which cellular components are broken down by the lysosomal activation. In this study, we aimed to examine the effects of imatinib on autophagy in addition to apoptosis in CML cells. Results suggested that imatinib induces autophagy in CML cells through inducing over-expression of BECLIN-1 and ATG5 genes with the statistical significance. Our results demonstrated that autophagy might be involved in imatinib-induced cell death.

引用

页码：95 / 99

页数：5

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