Natural Killer cell control of BRAFV600E mutant melanoma during targeted therapy

被引：10

作者：

de Andrade, Lucas Ferrari ^{[1
]}

Ngiow, Shin Foong ^{[1
]}

Martinet, Ludovic ^{[1
,2
]}

Smyth, Mark J. ^{[1
,3
]}

机构：

[1] QIMR Berghofer Med Res Inst, Immunol Canc & Infect Lab, Herston, Qld, Australia

[2] Canc Res Ctr Toulouse, UMR 1037, INSERM, Toulouse, France

[3] Univ Queensland, Sch Med, Herston, Qld, Australia

来源：

ONCOIMMUNOLOGY | 2015年 / 4卷 / 04期

关键词：

BRAF; cancer immunotherapy; metastases; NK cells; resistance; ANTIMELANOMA ACTIVITY; BRAF INHIBITORS;

D O I：

10.1080/2162402X.2014.998119

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Pharmacologic inhibition of the mutant BRAF(V600E) protein in advanced BRAFV600E melanoma results in a high proportion of patients that respond, but few with durable responses. We have recently revealed that Natural Killer (NK) cells play an essential role in the BRAF(V600E) inhibitor control of melanoma metastases in mice that may be therapeutically exploited to help overcome drug resistance.

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