Cdk5: A new player at synapses

被引：41

作者：

Cheng, K

Ip, NY ^{[1
]}

机构：

[1] Hong Kong Univ Sci & Technol, Dept Biochem, Mol Neurosci Ctr, Clear Water Bay, Hong Kong, Peoples R China

[2] Hong Kong Univ Sci & Technol, Dept Biochem, Biotechnol Res Inst, Clear Water Bay, Hong Kong, Peoples R China

来源：

NEUROSIGNALS | 2003年 / 12卷 / 4-5期

关键词：

Cdk5; p35; synapse; NMJ; cyclin;

D O I：

10.1159/000074619

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cdk5 is a member of the cyclin-dependent kinase family. Unlike other conventional Cdks that are major regulators of eukaryotic cell cycle progression, Cdk5 displays diverse functions in neuronal as well as non-neuronal tissues. In particular, accumulating evidence points to the roles of this kinase in CNS development and other cellular processes. In this article, we summarize the functional roles of Cdk5 pertaining to the formation and functions of synapse, a specialized structure for the fundamental functions of neurons. Copyright (C) 2003 S. Karger AG, Basel.

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页码：180 / 190

页数：11

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