FLT3: Receptor and ligand. Biology and potential clinical application

被引：77

作者：

Shurin, MR ^{[1
]}

Esche, C ^{[1
]}

Lotze, MT ^{[1
]}

机构：

[1] Univ Pittsburgh, Inst Canc, Dept Surg Oncol, Pittsburgh, PA 15213 USA

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 1998年 / 9卷 / 01期

关键词：

FLT3; FL; hematopoiesis; growth factors; dendritic cells;

D O I：

10.1016/S1359-6101(97)00035-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Flt3 ligand (PL) is a recently identified cytokine having a central role in the proliferation, survival and differentiation of early murine and human hematopoietic precursor/stem cells. FL acts synergistically in vitro with a number of other hematopoietic growth factors such as IL-3, IL-6, IL-11, IL-12, KIT Ligand and GM-CSF, Recently, it has been shown the in vivo administration of FL results in a significant alteration of hematopoiesis in murine bone marrow (BM), spleen, peripheral blood, liver and lymph nodes. In addition, treatment with FL resulted in a significant accumulation of functionally active dendritic cells within murine lymphoid tissues. The possible applications of FL in dendritic cell-based immunotherapies are discussed. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：37 / 48

页数：12

共 103 条

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