Retro-aldol cleavage of bafilomycin derivatives

被引：7

作者：

Granberg, KL ^{[1
]}

Edvinsson, KM ^{[1
]}

Nilsson, K ^{[1
]}

机构：

[1] Astra Hassle AB, Dept Med Chem, S-43183 Molndal, Sweden

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 04期

关键词：

biologically active compounds; cleavage reactions; macrolides;

D O I：

10.1016/S0040-4039(98)02365-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The intermediates 3 and 4, useful in the preparation of new biologically active bafilomycin derivatives, were obtained via a thermal retro-aldol reaction in diphenyl ether. The starting materials 5 and 7 for the retro-aldol reaction were synthesized in a few steps from bafilomycin C-1 (2) with or without a protective group at 7-OH. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：755 / 758

页数：4

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