Enhanced motor cortex facilitation in patients with vascular cognitive impairment-no dementia

被引：54

作者：

Bella, Rita ^{[1
]}

Ferri, Raffaele ^{[2
]}

Pennisi, Manuela ^{[3
]}

Cantone, Mariagiovanna ^{[1
]}

Lanza, Giuseppe ^{[1
]}

Malaguarnera, Giulia ^{[1
]}

Spampinato, Concetto ^{[4
]}

Giordano, Daniela ^{[4
]}

Alagona, Giovanna ^{[5
]}

Pennisi, Giovanni ^{[1
]}

机构：

[1] Univ Catania, Dept GF Ingrassia, Sect Neurosci, I-95123 Catania, Italy

[2] Oasi Inst Res Mental Retardat & Brain Aging IRCCS, Dept Neurol IC, I-94018 Troina, EN, Italy

[3] Univ Catania, Dept Chem, I-95125 Catania, Italy

[4] Univ Catania, Dept Elect Elect & Informat Engn, I-95125 Catania, Italy

[5] Cannizzaro Hosp, Dept Neurol, I-95126 Catania, Italy

来源：

NEUROSCIENCE LETTERS | 2011年 / 503卷 / 03期

关键词：

Subcortical ischemic vascular disease; Aging brain; Executive dysfunction; Neurophysiology; Transcranial Magnetic Stimulation; TRANSCRANIAL MAGNETIC STIMULATION; WHITE-MATTER LESIONS; INTRACORTICAL INHIBITION; CORTICAL EXCITABILITY; ALZHEIMERS-DISEASE; DISINHIBITION; DYSFUNCTION; BRAIN; STATE;

D O I：

10.1016/j.neulet.2011.08.022

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Data on Transcranial Magnetic Stimulation (TMS) derived measures of cortical excitability and intracortical circuits in age-related white matter changes are scarce. We aimed to assess early changes of motor cortex excitability in nondemented elderly patients with subcortical ischemic vascular disease (SVD). Ten SVD elderly and ten age-matched controls underwent paired-pulse TMS for the analysis of intracortical inhibition (ICI) and facilitation (ICF). All subjects performed neuropsychological assessment and brain magnetic resonance imaging. SVD patients showed abnormal executive control function. No statistically significant differences were found for resting motor threshold, cortical silent period between SVD patients and controls or between the two hemispheres, in patients. A significant enhancement of mean ICF was observed in SVD patients. This study provides the first evidence of functional changes in intracortical excitatory neuronal circuits in patients with SVD and clinical features of vascular cognitive impairment-no dementia. Further studies are required to evaluate whether the observed change of ICF might predict cognitive and/or motor impairment in a population at risk for subcortical vascular dementia. Crown Copyright (C) 2011 Published by Elsevier Ireland Ltd. All rights reserved.

引用

页码：171 / 175

页数：5

共 43 条

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