Treating Human Autoimmunity: Current Practice and Future Prospects

被引：150

作者：

Rosenblum, Michael D. ^{[1
]}

Gratz, Iris K. ^{[2
]}

Paw, Jonathan S. ^{[1
]}

Abbas, Abul K. ^{[2
]}

机构：

[1] Univ Calif San Francisco, Dept Dermatol, San Francisco, CA 94115 USA

[2] Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94143 USA

来源：

SCIENCE TRANSLATIONAL MEDICINE | 2012年 / 4卷 / 125期

关键词：

REGULATORY T-CELLS; TRANSCRIPTION FACTOR FOXP3; PLACEBO-CONTROLLED TRIAL; IN-VIVO EXPANSION; DOUBLE-BLIND; PHASE-II; RHEUMATOID-ARTHRITIS; IMMUNE-RESPONSES; CO-STIMULATION; CLINICAL-TRIAL;

D O I：

10.1126/scitranslmed.3003504

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Autoimmune diseases are caused by immune cells attacking the host tissues they are supposed to protect. Recent advances suggest that maintaining a balance of effector and regulatory immune function is critical for avoiding autoimmunity. New therapies, including costimulation blockade, regulatory T cell therapy, antigen-specific immunotherapy, and manipulating the interleukin-2 pathway, attempt to restore this balance. This review discusses these advances as well as the challenges that must be overcome to target these therapies to patients suffering from autoimmune disease while avoiding the pitfalls of general immunosuppression.

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