Mycoplasma genitalium:: prevalence, clinical significance, and transmission

被引:163
作者
Anagrius, C [1 ]
Loré, B
Jensen, JS
机构
[1] Dept Venereol, SE-79182 Falun, Sweden
[2] Dept Clin Microbiol, SE-79182 Falun, Sweden
[3] Statens Serum Inst, Mycoplasma Lab, DK-2300 Copenhagen, Denmark
关键词
D O I
10.1136/sti.2004.012062
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Objectives: To study the prevalence, symptoms and signs of Mycoplasma genitalium and Chlamydia trachomatis infections in STD clinic attendees and in partners of M genitalium infected patients. Methods: M genitalium and C trachomatis were detected by polymerase chain reaction from urethral and endocervical swab specimens in a cross sectional study among 445 female and 501 male STD clinic attendees. Partners of 26 female and 26 male M genitalium positive index patients were examined. Results: The prevalence of C trachomatis and M genitalium was 4% and 6.3%, respectively, among the women and 5.4% and 6%, respectively, among the men. Dual infections were uncommon. M genitalium was strongly associated with urethritis in both men and women and with cervicitis in women. Among M genitalium infected men, symptomatic urethritis was more common than asymptomatic urethritis. M genitalium and C trachomatis were not associated with symptoms of urethritis or cervicitis in women. Of 26 male partners of M genitalium positive female index patients, 38% were positive, and 77% of the negative partners had symptoms of urethritis. The concordance rate for 22 female partners of male index patients was 45%. For both men and women the M genitalium prevalence was significantly higher in partners of M genitalium positive index patients than in M genitalium negative index patients with urethritis and/or cervicitis. Conclusions: M genitalium is associated with urethritis in both men and women and with cervicitis in women. A high concordance rate was found among sexual partners of M genitalium infected patients, indicating that the infection is sexually transmitted.
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页码:458 / 462
页数:5
相关论文
共 22 条
[1]   Mycoplasma genitalium in non-gonococcal urethritis -: a study in Swedish male STD patients [J].
Björnelius, E ;
Lidbrink, P ;
Jensen, JS .
INTERNATIONAL JOURNAL OF STD & AIDS, 2000, 11 (05) :292-296
[2]   High prevalence of Mycoplasma genitalium in the lower genitourinary tract of women attending a sexually transmitted disease clinic in Paris, France [J].
Casin, I ;
Vexiau-Robert, D ;
De la Salmonière, P ;
Eche, A ;
Grandry, B ;
Janier, M .
SEXUALLY TRANSMITTED DISEASES, 2002, 29 (06) :353-359
[3]   Association between Mycoplasma genitalium and acute endometritis [J].
Cohen, CR ;
Manhart, LE ;
Bukusi, EA ;
Astete, S ;
Brunham, RC ;
Holmes, KK ;
Sinei, SK ;
Bwayo, JJ ;
Totten, PA .
LANCET, 2002, 359 (9308) :765-766
[4]   Contact tracing for genital Chlamydia trachomatis in a Swedish county [J].
Eitrem, R ;
Erenius, M ;
Meeuwisse, A .
SEXUALLY TRANSMITTED DISEASES, 1998, 25 (08) :433-436
[5]   Symptomatic urethritis is more prevalent in men infected with Mycoplasma genitalium than with Chlamydia trachomatis [J].
Falk, L ;
Fredlund, H ;
Jensen, JS .
SEXUALLY TRANSMITTED INFECTIONS, 2004, 80 (04) :289-293
[6]  
FALK L, IN PRESS SEX TRANSM
[7]   MYCOPLASMA-GENITALIUM AND NONGONOCOCCAL URETHRITIS [J].
HORNER, PJ ;
TAYLORROBINSON, D .
LANCET, 1994, 343 (8900) :790-791
[8]   POLYMERASE CHAIN-REACTION FOR DETECTION OF MYCOPLASMA-GENITALIUM IN CLINICAL-SAMPLES [J].
JENSEN, JS ;
ULDUM, SA ;
SONDERGARDANDERSEN, J ;
VUUST, J ;
LIND, K .
JOURNAL OF CLINICAL MICROBIOLOGY, 1991, 29 (01) :46-50
[9]   Use of TaqMan 5′ nuclease real-time PCR for quantitative detection of Mycoplasma genitalium DNA in males with and without urethritis who were attendees at a sexually transmitted disease clinic [J].
Jensen, JS ;
Björnelius, E ;
Dohn, B ;
Lidbrink, P .
JOURNAL OF CLINICAL MICROBIOLOGY, 2004, 42 (02) :683-692
[10]   Mycoplasma genitalium:: the aetiological agent of urethritis and other sexually transmitted diseases [J].
Jensen, JS .
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2004, 18 (01) :1-11