A novel amino acid substitution at the receptor-binding site on the hemagglutinin of H3N2 influenza A viruses isolated from 6 cases with acute encephalopathy during the 1997-1998 season in Tokyo

被引：24

作者：

Mori, SI ^{[1
]}

Nagashima, M ^{[1
]}

Sasaki, Y ^{[1
]}

Mori, K ^{[1
]}

Tabei, Y ^{[1
]}

Yoshida, Y ^{[1
]}

Yamazaki, K ^{[1
]}

Hirata, I ^{[1
]}

Sekine, H ^{[1
]}

Ito, T ^{[1
]}

Suzuki, S ^{[1
]}

机构：

[1] Tokyo Metropolitan Res Inst Publ Hlth, Dept Microbiol, Div Virol, Shinjuku Ku, Tokyo 1690073, Japan

来源：

ARCHIVES OF VIROLOGY | 1999年 / 144卷 / 01期

关键词：

D O I：

10.1007/s007050050491

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We analyzed the hemagglutinin (HA) genes of influenza A viruses consisting of 6 strains isolated from cerebrospinal fluids of patients with encephalopathy and 3 isolates from throat washes of patients without central nervous system symptoms during the 1997-1998 season in Tokyo. Aligned 9 amino acid sequences showed 7 common substitutions compared with A/Wuhan/359/95 (vaccine strain used in the season in Japan), which were allocated to three different antigenic sites on the H3 HA molecule. It is noted that a novel substitution at the receptor-binding site (Tyr-137 to Phe) was found exclusively in the isolates from the patients with encephalopathy.

引用

页码：147 / 155

页数：9

共 39 条

[1] CELL TROPISM OF INFLUENZA-VIRUS MEDIATED BY HEMAGGLUTININ ACTIVATION AT THE STAGE OF VIRUS ENTRY [J].